Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4920795..4921311 Replicon chromosome
Accession NZ_CP082765
Organism Klebsiella pneumoniae strain 12

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag FTO26_RS24325 Protein ID WP_002886902.1
Coordinates 4920795..4921079 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag FTO26_RS24330 Protein ID WP_002886901.1
Coordinates 4921069..4921311 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FTO26_RS24300 (FTO26_024300) 4916279..4916542 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
FTO26_RS24305 (FTO26_024305) 4916672..4916845 + 174 WP_002886906.1 hypothetical protein -
FTO26_RS24310 (FTO26_024310) 4916848..4917591 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
FTO26_RS24315 (FTO26_024315) 4917948..4920086 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
FTO26_RS24320 (FTO26_024320) 4920327..4920791 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
FTO26_RS24325 (FTO26_024325) 4920795..4921079 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FTO26_RS24330 (FTO26_024330) 4921069..4921311 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
FTO26_RS24335 (FTO26_024335) 4921389..4923299 - 1911 WP_004152270.1 PRD domain-containing protein -
FTO26_RS24340 (FTO26_024340) 4923322..4924476 - 1155 WP_002886900.1 lactonase family protein -
FTO26_RS24345 (FTO26_024345) 4924542..4925282 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T214812 WP_002886902.1 NZ_CP082765:c4921079-4920795 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T214812 NZ_CP110260:c2776075-2775764 [Escherichia albertii]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGAACGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTCTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT214812 WP_002886901.1 NZ_CP082765:c4921311-4921069 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT214812 NZ_CP110260:c2775763-2775473 [Escherichia albertii]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
ACGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCCGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References