Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4202412..4203031 Replicon chromosome
Accession NZ_CP082765
Organism Klebsiella pneumoniae strain 12

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag FTO26_RS20885 Protein ID WP_002892050.1
Coordinates 4202813..4203031 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag FTO26_RS20880 Protein ID WP_002892066.1
Coordinates 4202412..4202786 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FTO26_RS20870 (FTO26_020870) 4197564..4198757 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
FTO26_RS20875 (FTO26_020875) 4198780..4201926 + 3147 WP_020326861.1 multidrug efflux RND transporter permease subunit AcrB -
FTO26_RS20880 (FTO26_020880) 4202412..4202786 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
FTO26_RS20885 (FTO26_020885) 4202813..4203031 + 219 WP_002892050.1 HHA domain-containing protein Toxin
FTO26_RS20890 (FTO26_020890) 4203190..4203756 + 567 WP_002892030.1 maltose O-acetyltransferase -
FTO26_RS20895 (FTO26_020895) 4203728..4203868 - 141 WP_004147370.1 hypothetical protein -
FTO26_RS20900 (FTO26_020900) 4203889..4204359 + 471 WP_002892026.1 YlaC family protein -
FTO26_RS20905 (FTO26_020905) 4204334..4205785 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
FTO26_RS20910 (FTO26_020910) 4205886..4206584 + 699 WP_002892021.1 GNAT family protein -
FTO26_RS20915 (FTO26_020915) 4206581..4206721 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
FTO26_RS20920 (FTO26_020920) 4206721..4206984 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T214810 WP_002892050.1 NZ_CP082765:4202813-4203031 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T214810 NZ_CP110260:2239887-2240039 [Escherichia albertii]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTCTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT214810 WP_002892066.1 NZ_CP082765:4202412-4202786 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT214810 NZ_CP110260:c2239838-2239781 [Escherichia albertii]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References