Detailed information of TA system TA021481

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 803182..803659
• Replicon: chromosome
• Accession: NC_007795
• Organism: Staphylococcus aureus subsp. aureus NCTC 8325

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: Q2G005
• Locus tag: SAOUHSC_00823
• Protein ID: YP_499378.1
• Coordinates: 803182..803370 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: Q2G004
• Locus tag: SAOUHSC_00824
• Protein ID: YP_499379.1
• Coordinates: 803399..803659 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SAOUHSC_00817	799223..799693	+	471	YP_499372.1	hypothetical protein	-
SAOUHSC_00818	800034..800720	+	687	YP_499373.1	thermonuclease	-
SAOUHSC_00819	801077..801277	+	201	YP_499374.1	hypothetical protein	-
SAOUHSC_00820	801773..801991	-	219	YP_499375.1	hypothetical protein	-
SAOUHSC_00821	802053..802337	-	285	YP_499376.1	hypothetical protein	-
SAOUHSC_00822	802425..802994	-	570	YP_499377.1	hypothetical protein	-
SAOUHSC_00823	803182..803370	-	189	YP_499378.1	hypothetical protein	Toxin
SAOUHSC_00824	803399..803659	-	261	YP_499379.1	hypothetical protein	Antitoxin
SAOUHSC_00825	804000..804203	+	204	YP_499380.1	hypothetical protein	-
SAOUHSC_00826	804200..804436	-	237	YP_499381.1	hypothetical protein	-
SAOUHSC_00827	804682..805242	+	561	YP_499382.1	hypothetical protein	-
SAOUHSC_00828	805315..805932	-	618	YP_499383.1	hypothetical protein	-
SAOUHSC_00830	806087..806581	-	495	YP_499384.1	hypothetical protein	-
SAOUHSC_00831	806980..807402	-	423	YP_499385.1	hypothetical protein	-
SAOUHSC_00832	807550..808266	+	717	YP_499386.1	3-dehydroquinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (26-98)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7172.84 Da
• Isoelectric Point: 9.9971

>T21481 YP_499378.1 NC_007795:c803370-803182 [Staphylococcus aureus subsp. aureus NCTC 8325]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Nucleotide

• Length: 189 bp

>T21481 NC_007795:c803370-803182 [Staphylococcus aureus subsp. aureus NCTC 8325]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9940.09 Da
• Isoelectric Point: 4.0624

>AT21481 YP_499379.1 NC_007795:c803659-803399 [Staphylococcus aureus subsp. aureus NCTC 8325]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Nucleotide

• Length: 261 bp

>AT21481 NC_007795:c803659-803399 [Staphylococcus aureus subsp. aureus NCTC 8325]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Structures

Toxin

• AlphaFold DB: Q2G005

Antitoxin

• AlphaFold DB: Q2G004