Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2742040..2743628 Replicon chromosome
Accession NZ_CP082765
Organism Klebsiella pneumoniae strain 12

Toxin (Protein)


Gene name hipA Uniprot ID A0A0H3GN97
Locus tag FTO26_RS13545 Protein ID WP_004199851.1
Coordinates 2742040..2743362 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag FTO26_RS13550 Protein ID WP_002904790.1
Coordinates 2743362..2743628 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FTO26_RS13530 (FTO26_013530) 2737105..2739606 + 2502 WP_004199853.1 fimbria/pilus outer membrane usher protein -
FTO26_RS13535 (FTO26_013535) 2739594..2740598 + 1005 WP_004199852.1 fimbrial protein -
FTO26_RS13540 (FTO26_013540) 2740731..2742023 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
FTO26_RS13545 (FTO26_013545) 2742040..2743362 - 1323 WP_004199851.1 type II toxin-antitoxin system HipA family toxin Toxin
FTO26_RS13550 (FTO26_013550) 2743362..2743628 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
FTO26_RS13555 (FTO26_013555) 2743894..2744220 - 327 WP_002904788.1 hydroxyisourate hydrolase -
FTO26_RS13560 (FTO26_013560) 2744217..2744717 - 501 WP_002904787.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
FTO26_RS13565 (FTO26_013565) 2744695..2746074 - 1380 WP_004199850.1 nucleobase:cation symporter-2 family protein -
FTO26_RS13570 (FTO26_013570) 2746420..2747574 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
FTO26_RS13575 (FTO26_013575) 2747555..2748478 - 924 WP_004199849.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49128.44 Da        Isoelectric Point: 7.2487

>T214809 WP_004199851.1 NZ_CP082765:c2743362-2742040 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPLEQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T214809 NZ_CP110260:1596206-1596424 [Escherichia albertii]
ATGTCCGATAAACCTTTAACAAAAACCGATTATTTGATGCGTCTGCGTCGTTGCCAGACAATTGACACACTGGAACGTGT
TATCGAGAAAAATAAATATGAATTATCAGATAATGAATTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTTGCAGAGC
TGACTATGAATAAGCTATATGACAAGATCCCTTCCTCAGTGTGGAAATTCATTCGGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT214809 WP_002904790.1 NZ_CP082765:c2743628-2743362 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT214809 NZ_CP110260:1595806-1596180 [Escherichia albertii]
ATGGATGAATACTCACCAAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGTAACCATGGCTGGGTAAATGACCCAACCTCGGCAATCAATCTACAGCTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAACAGATTGATGAATATCTG
GACGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAACCGATT
GTTCCGTTGCTTTGTTAACGCCACCAAAGCGAATCCTGCAAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GN97

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References