Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 876580..877234 Replicon chromosome
Accession NZ_CP082765
Organism Klebsiella pneumoniae strain 12

Toxin (Protein)


Gene name cptA Uniprot ID R4YHX2
Locus tag FTO26_RS04400 Protein ID WP_004144731.1
Coordinates 876827..877234 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag FTO26_RS04395 Protein ID WP_002916312.1
Coordinates 876580..876846 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FTO26_RS04370 (FTO26_004370) 871736..873169 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
FTO26_RS04375 (FTO26_004375) 873288..874016 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
FTO26_RS04380 (FTO26_004380) 874066..874377 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
FTO26_RS04385 (FTO26_004385) 874541..875200 + 660 WP_002916317.1 hemolysin III family protein -
FTO26_RS04390 (FTO26_004390) 875351..876334 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
FTO26_RS04395 (FTO26_004395) 876580..876846 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
FTO26_RS04400 (FTO26_004400) 876827..877234 + 408 WP_004144731.1 protein YgfX Toxin
FTO26_RS04405 (FTO26_004405) 877241..877762 - 522 WP_002916308.1 flavodoxin FldB -
FTO26_RS04410 (FTO26_004410) 877863..878759 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
FTO26_RS04415 (FTO26_004415) 878782..879495 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
FTO26_RS04420 (FTO26_004420) 879501..881234 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15936.69 Da        Isoelectric Point: 11.4778

>T214800 WP_004144731.1 NZ_CP082765:876827-877234 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNAE
WEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 408 bp

>T214800 NZ_CP110258:3404115-3404333 [Escherichia albertii]
ATGTCCGATAAACCTTTAACAAAAACCGATTATTTGATGCGTCTGCGTCGTTGCCAGACAATTGACACGCTGGAACGTGT
TATCGAGAAAAATAAATATGAATTATCAGATAATGAATTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTTGCAGAGC
TGACTATGAATAAGCTATATGACAAGATCCCTTCCTCAGTGTGGAAATTCATTCGGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT214800 WP_002916312.1 NZ_CP082765:876580-876846 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT214800 NZ_CP110258:3403715-3404089 [Escherichia albertii]
ATGGATGAATACTCACCAAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGTAACCATGGCTGGGTAAATGACCCAACCTCGGCAATCAATCTACAGCTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAACAGATTGATGAATATCTG
GACGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAACCGATT
GTTCCGTTGCTTTGTTAACGCCACCAAAGCGAATCCTGCAAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378E4P6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References