Detailed information of TA system
Overview
TA module
Type | II | Classification (family/domain) | vagCD/VapC-VagC |
Location | 124157..124827 | Replicon | plasmid pKP36-vir |
Accession | NZ_CP082760 | ||
Organism | Klebsiella pneumoniae strain 36 |
Toxin (Protein)
Gene name | vagD | Uniprot ID | Q6U619 |
Locus tag | FTO14_RS27715 | Protein ID | WP_004213072.1 |
Coordinates | 124157..124600 (-) | Length | 148 a.a. |
Antitoxin (Protein)
Gene name | vagC | Uniprot ID | Q6U620 |
Locus tag | FTO14_RS27720 | Protein ID | WP_004213073.1 |
Coordinates | 124597..124827 (-) | Length | 77 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
FTO14_RS27680 (FTO14_027680) | 119568..119843 | + | 276 | WP_004213932.1 | carboxymuconolactone decarboxylase family protein | - |
FTO14_RS27685 (FTO14_027685) | 119906..120397 | + | 492 | WP_011251327.1 | DM13 domain-containing protein | - |
FTO14_RS27690 (FTO14_027690) | 120446..121366 | + | 921 | WP_004213934.1 | DUF1471 domain-containing protein | - |
FTO14_RS27695 (FTO14_027695) | 121457..121860 | + | 404 | Protein_140 | GAF domain-containing protein | - |
FTO14_RS27700 (FTO14_027700) | 122378..123013 | - | 636 | Protein_141 | mucoid phenotype regulator RmpA2 | - |
FTO14_RS27705 (FTO14_027705) | 123430..123734 | + | 305 | Protein_142 | transposase | - |
FTO14_RS29785 | 123757..124008 | - | 252 | WP_186987481.1 | hypothetical protein | - |
FTO14_RS27715 (FTO14_027715) | 124157..124600 | - | 444 | WP_004213072.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
FTO14_RS27720 (FTO14_027720) | 124597..124827 | - | 231 | WP_004213073.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
FTO14_RS27725 (FTO14_027725) | 125435..126568 | + | 1134 | WP_004213075.1 | DUF3800 domain-containing protein | - |
FTO14_RS27730 (FTO14_027730) | 126584..126877 | + | 294 | WP_004213076.1 | hypothetical protein | - |
FTO14_RS27735 (FTO14_027735) | 126867..127073 | - | 207 | WP_004213077.1 | hypothetical protein | - |
FTO14_RS27740 (FTO14_027740) | 127425..127715 | + | 291 | WP_004213078.1 | hypothetical protein | - |
FTO14_RS27745 (FTO14_027745) | 127705..128604 | + | 900 | WP_004225022.1 | nucleotide-binding protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Mobilizable plasmid | - | iroN / rmpA / iucA / iucB / iucC / iucD / iutA / rmpA2 | 1..197408 | 197408 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 148 a.a. Molecular weight: 16006.74 Da Isoelectric Point: 9.3642
>T214791 WP_004213072.1 NZ_CP082760:c124600-124157 [Klebsiella pneumoniae]
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFERVPGLVLEDWVKKAALCRVIS
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFERVPGLVLEDWVKKAALCRVIS
Download Length: 444 bp
>T214791 NZ_CP110258:166254-166406 [Escherichia albertii]
ATGCCGCAGAAATATAGATTGCTTTCTTTAATAGTGATTTGTTTCACGCTTTTATTTTTCACCTGGATGATAAGGGATTC
ACTGTGTGAATTGCATATTAAACAGGGGAGTTATGAGCTGGCGGCGTTTTTAGCCTGCAATTTGAAAGAGTAA
ATGCCGCAGAAATATAGATTGCTTTCTTTAATAGTGATTTGTTTCACGCTTTTATTTTTCACCTGGATGATAAGGGATTC
ACTGTGTGAATTGCATATTAAACAGGGGAGTTATGAGCTGGCGGCGTTTTTAGCCTGCAATTTGAAAGAGTAA
Antitoxin
Download Length: 77 a.a. Molecular weight: 8677.73 Da Isoelectric Point: 4.4563
>AT214791 WP_004213073.1 NZ_CP082760:c124827-124597 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRAAPDFMAEREDVVSDEGRFEP
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRAAPDFMAEREDVVSDEGRFEP
Download Length: 231 bp
>AT214791 NZ_CP110258:c166197-166149 [Escherichia albertii]
GCATAGAGGGGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG
GCATAGAGGGGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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