Detailed information of TA system TA214786

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 5075195..5076876
• Replicon: chromosome
• Accession: NZ_CP082759
• Organism: Klebsiella pneumoniae strain 36

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: W8V1Q6
• Locus tag: FTO14_RS25125
• Protein ID: WP_002885155.1
• Coordinates: 5075195..5076112 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: W8UPQ8
• Locus tag: FTO14_RS25130
• Protein ID: WP_004151732.1
• Coordinates: 5076118..5076876 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FTO14_RS25105 (FTO14_025105)	5070501..5072021	+	1521	WP_002885173.1	sugar ABC transporter ATP-binding protein	-
FTO14_RS25110 (FTO14_025110)	5072018..5073016	+	999	WP_002885172.1	ribose ABC transporter permease	-
FTO14_RS25115 (FTO14_025115)	5073047..5073988	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
FTO14_RS25120 (FTO14_025120)	5074063..5075070	+	1008	WP_004151731.1	carbohydrate kinase family protein	-
FTO14_RS25125 (FTO14_025125)	5075195..5076112	-	918	WP_002885155.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
FTO14_RS25130 (FTO14_025130)	5076118..5076876	-	759	WP_004151732.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
FTO14_RS25135 (FTO14_025135)	5076962..5077690	-	729	WP_002885152.1	response regulator transcription factor	-
FTO14_RS25140 (FTO14_025140)	5077963..5080110	+	2148	WP_077598858.1	formate dehydrogenase subunit alpha	-
FTO14_RS25145 (FTO14_025145)	5080340..5081026	+	687	WP_004151733.1	tetratricopeptide repeat protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system (95-246)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34687.15 Da
• Isoelectric Point: 5.4707

>T214786 WP_002885155.1 NZ_CP082759:c5076112-5075195 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

>T214786 NZ_CP110233:32586-32861 [Vagococcus sp. STAA11]
ATGATAGAAAAAAAATACACTGTTCGATATGAGAAAAATGCTCAAAAAGCATTAAAAAAAATGGATAAACATCAAGCCAT
GCTCATATTATCTTGGATTTCTAAAAATTTAGAGGGAACAGATTCACCACGTGTTCATGGTAAAGGATTAGTAGGAAACA
AAAGCGGTCAATGGCGATATAGAATTGGTGATTATCGCTTATTAGCCAATATAGATGATGAAACGATCACAATTTTAGTA
TTAGAAATTGGTCACCGTAGAGAAATTTATAAGTAA

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28564.92 Da
• Isoelectric Point: 10.0870

>AT214786 WP_004151732.1 NZ_CP082759:c5076876-5076118 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLSFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

>AT214786 NZ_CP110233:32368-32589 [Vagococcus sp. STAA11]
ATGAGTACTGTAACATTTAGAGTTACTGATGAAGAAAAATCTTTCATTCAATCTATGGCTGATCTTAACGGACAAACCTT
ATCAGAATTAGCTAGAACTAAATTATTAGAAGGATTAGAAGATCAAATAGATATGGGTTTATATGAAAAAGCTATGAAAG
CACATGAGGAAAAAGACGAAAGTATTTCGCATCAGGATATGCTTAGAGAGTTAGGGTTATGA

Structures

Toxin

• AlphaFold DB: A0A0H3GH11

Antitoxin

• AlphaFold DB: A0A0H3GQB5