Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4919011..4919527 Replicon chromosome
Accession NZ_CP082759
Organism Klebsiella pneumoniae strain 36

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag FTO14_RS24325 Protein ID WP_002886902.1
Coordinates 4919011..4919295 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag FTO14_RS24330 Protein ID WP_002886901.1
Coordinates 4919285..4919527 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FTO14_RS24300 (FTO14_024300) 4914495..4914758 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
FTO14_RS24305 (FTO14_024305) 4914888..4915061 + 174 WP_002886906.1 hypothetical protein -
FTO14_RS24310 (FTO14_024310) 4915064..4915807 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
FTO14_RS24315 (FTO14_024315) 4916164..4918302 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
FTO14_RS24320 (FTO14_024320) 4918543..4919007 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
FTO14_RS24325 (FTO14_024325) 4919011..4919295 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FTO14_RS24330 (FTO14_024330) 4919285..4919527 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
FTO14_RS24335 (FTO14_024335) 4919605..4921515 - 1911 WP_004152270.1 PRD domain-containing protein -
FTO14_RS24340 (FTO14_024340) 4921538..4922692 - 1155 WP_002886900.1 lactonase family protein -
FTO14_RS24345 (FTO14_024345) 4922758..4923498 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T214785 WP_002886902.1 NZ_CP082759:c4919295-4919011 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T214785 NZ_CP110233:7102-7293 [Vagococcus sp. STAA11]
ATGCCAATGACGATAAAAGAAGCAGAGCAATTGCTTAAGGATTCTGGTTTCATTGAAGTGAAGGGTGGTAAAGGTTCTCA
CAGAAAGTTTATTAAAGCTGGATGTACGAGGCCTATGATATTAACTAGTCACGGAAAAGAGCTATCTAGAGTTGTTGAAC
AATCTGTTTTAAAGGCGGTAGGCTTGAAATAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT214785 WP_002886901.1 NZ_CP082759:c4919527-4919285 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT214785 NZ_CP110233:7335-7721 [Vagococcus sp. STAA11]
GTGAAAAAAGTATATCCTGCGATATTTGAAGAAGACGAAGTTGGTTACGGTATTTACTTCCCAGATGTAGAGGGAGCAGT
AACACAAGGTGATTCAATACAAAATGGATTAGAAATGGCTTCAGATGCATTAGGTATTATCTTAGCTGATATGTTAGAAA
GCGGAGAAGATTTGCCAAAAGCTAGTAAAATTAATGAGGTTAGTTACGAAGAAAATGAACAATTTGTTACCCTTGTATCT
GTTGATTTAACAGATTATTTAAAAGACGGAAAGTTAGATAAGAAAACAATAACGATTCCACATTGGTTGAACATGAGAGC
CAAGCAATCAGGGATTAATTTTTCTGAAACGCTAACTACAGCTTTAGAAAATAAGTTAAATTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References