Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4202540..4203159 Replicon chromosome
Accession NZ_CP082759
Organism Klebsiella pneumoniae strain 36

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag FTO14_RS20900 Protein ID WP_002892050.1
Coordinates 4202941..4203159 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag FTO14_RS20895 Protein ID WP_002892066.1
Coordinates 4202540..4202914 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FTO14_RS20885 (FTO14_020885) 4197692..4198885 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
FTO14_RS20890 (FTO14_020890) 4198908..4202054 + 3147 WP_020326861.1 multidrug efflux RND transporter permease subunit AcrB -
FTO14_RS20895 (FTO14_020895) 4202540..4202914 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
FTO14_RS20900 (FTO14_020900) 4202941..4203159 + 219 WP_002892050.1 HHA domain-containing protein Toxin
FTO14_RS20905 (FTO14_020905) 4203318..4203884 + 567 WP_002892030.1 maltose O-acetyltransferase -
FTO14_RS20910 (FTO14_020910) 4203856..4203996 - 141 WP_004147370.1 hypothetical protein -
FTO14_RS20915 (FTO14_020915) 4204017..4204487 + 471 WP_002892026.1 YlaC family protein -
FTO14_RS20920 (FTO14_020920) 4204462..4205913 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
FTO14_RS20925 (FTO14_020925) 4206014..4206712 + 699 WP_002892021.1 GNAT family protein -
FTO14_RS20930 (FTO14_020930) 4206709..4206849 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
FTO14_RS20935 (FTO14_020935) 4206849..4207112 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T214783 WP_002892050.1 NZ_CP082759:4202941-4203159 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T214783 NZ_CP110231:c2259567-2259289 [Selenomonas sputigena]
ATGCAGTATGAATTGAAGTACACACGCGCCTTTCGTCGAGGCTACAAACGCGCCAAAAAGCGAGGACTGAATCTTTCGCT
TCTCGGTGAAATCGTGGAAATGCTGCGTTGTGGCAAGAAACTGCCTAAAAAATATGCCGATCATTGCCTCAGTGGCGATT
TTTCCCAATGCCGTGAATGTCATATTCAACCAGATTGGCTGCTCGTCTACCGCATCGATGACGACATTCTAACATTGACC
TTGATGGATACGGGAACTCATGCAGAATTATTCCATTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT214783 WP_002892066.1 NZ_CP082759:4202540-4202914 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT214783 NZ_CP110231:c2259841-2259557 [Selenomonas sputigena]
ATGGCAACCGTATCCGCACAAATCCGACTCGATCCCGAAGTCAAGGCACGCTCCATGGCGCTTTTTCAAAGCCTCGGACT
CGACCTATCCACAGCCGTCAACGTATTCCTGCGCCAATGCCTGATCCATCGCGGCCTGCCGTTCAGCGTGAAGGAGGGAA
CCTACTCCGCTGAATTGCTTGAGGCTATTGCAGAGGCTGAGCAGATCGCACACGATCCATCTGTGCCATCTTACAAGAGC
TGGAAAGAACTAGAAGAAGCCTTGGAGAGCGAACATGCAGTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References