Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2743206..2744794 Replicon chromosome
Accession NZ_CP082759
Organism Klebsiella pneumoniae strain 36

Toxin (Protein)


Gene name hipA Uniprot ID A0A0H3GN97
Locus tag FTO14_RS13570 Protein ID WP_004199851.1
Coordinates 2743206..2744528 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag FTO14_RS13575 Protein ID WP_002904790.1
Coordinates 2744528..2744794 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FTO14_RS13555 (FTO14_013555) 2738271..2740772 + 2502 WP_004199853.1 fimbria/pilus outer membrane usher protein -
FTO14_RS13560 (FTO14_013560) 2740760..2741764 + 1005 WP_004199852.1 fimbrial protein -
FTO14_RS13565 (FTO14_013565) 2741897..2743189 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
FTO14_RS13570 (FTO14_013570) 2743206..2744528 - 1323 WP_004199851.1 type II toxin-antitoxin system HipA family toxin Toxin
FTO14_RS13575 (FTO14_013575) 2744528..2744794 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
FTO14_RS13580 (FTO14_013580) 2745060..2745386 - 327 WP_002904788.1 hydroxyisourate hydrolase -
FTO14_RS13585 (FTO14_013585) 2745383..2745883 - 501 WP_002904787.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
FTO14_RS13590 (FTO14_013590) 2745861..2747240 - 1380 WP_004199850.1 nucleobase:cation symporter-2 family protein -
FTO14_RS13595 (FTO14_013595) 2747586..2748740 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
FTO14_RS13600 (FTO14_013600) 2748721..2749644 - 924 WP_004199849.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49128.44 Da        Isoelectric Point: 7.2487

>T214782 WP_004199851.1 NZ_CP082759:c2744528-2743206 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPLEQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T214782 NZ_CP110231:c2199494-2199228 [Selenomonas sputigena]
ATGAAATCCTATCGCTTGATCTACTCCGAGCGTGCAAAGAAAGATGTCAAGAAGCTTGATCCATACACCAAGCAGATGAT
CAAGTCGTGGATTGAGAAGCGGCTGCTGCACTCGGAAAATCCTCGTGCACACGGCAAGGCGCTCACGGGAAACCACAAGG
GCGAATGGCGCTACCGCATCGGCGACTACCGTCTGATCTGCGCCATTGAGGACGAGCGGCTCGTTATCCTCGCCCTCGCC
CTCGGGCACAGGCGCGAGGTGTATTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT214782 WP_002904790.1 NZ_CP082759:c2744794-2744528 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT214782 NZ_CP110231:c2199712-2199491 [Selenomonas sputigena]
ATGAGCTTTTCCATCCGACTGACGGACACGGAGCGGGCGCTCGCTGAAAGCTACGCGAAGCTGCACGCGCTCTCGCTCGC
CGAAGCATTCAAGCGGGCGCTCTTCGAAAAGATCGAAGACGAGTACGACATCGCGCTTGCCGACGAGGCGTATGAGGAGT
ATCTGGCAAACCCTACGACATACTCTCACGAGGAATTTTGGAATGATGTGATGACGCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GN97

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References