Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 4815474..4816284 Replicon chromosome
Accession NZ_CP082753
Organism Klebsiella pneumoniae strain 37

Toxin (Protein)


Gene name KacT Uniprot ID A0A0H3GMP0
Locus tag FTO11_RS23845 Protein ID WP_002887280.1
Coordinates 4815474..4816007 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag FTO11_RS23850 Protein ID WP_002887278.1
Coordinates 4816018..4816284 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FTO11_RS23840 (FTO11_023835) 4814305..4815426 + 1122 WP_002887282.1 cupin domain-containing protein -
FTO11_RS23845 (FTO11_023840) 4815474..4816007 - 534 WP_002887280.1 type II toxin-antitoxin system toxin KacT Toxin
FTO11_RS23850 (FTO11_023845) 4816018..4816284 - 267 WP_002887278.1 type II toxin-antitoxin system antitoxin KacA Antitoxin
FTO11_RS23855 (FTO11_023850) 4816387..4817820 - 1434 WP_002887275.1 Cu(+)/Ag(+) sensor histidine kinase -
FTO11_RS23860 (FTO11_023855) 4817810..4818493 - 684 WP_002887273.1 copper response regulator transcription factor CusR -
FTO11_RS23865 (FTO11_023860) 4818665..4820050 + 1386 WP_002887267.1 efflux transporter outer membrane subunit -
FTO11_RS23870 (FTO11_023865) 4820068..4820412 + 345 WP_002887266.1 cation efflux system protein CusF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19838.70 Da        Isoelectric Point: 5.2614

>T214757 WP_002887280.1 NZ_CP082753:c4816007-4815474 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHVMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

>T214757 NZ_CP110220:c2437533-2437378 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT214757 WP_002887278.1 NZ_CP082753:c4816284-4816018 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp

>AT214757 NZ_CP110220:2437545-2437603 [Salmonella enterica subsp. enterica serovar Enteritidis]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGCAAAGCATGAAATTGGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5ZGN
PDB 5XUN

Antitoxin

Source ID Structure
PDB 5ZGN
AlphaFold DB A0A0H3GLZ1

References