Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 878905..879559 Replicon chromosome
Accession NZ_CP082753
Organism Klebsiella pneumoniae strain 37

Toxin (Protein)


Gene name cptA Uniprot ID R4YHX2
Locus tag FTO11_RS04430 Protein ID WP_004144731.1
Coordinates 879152..879559 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag FTO11_RS04425 Protein ID WP_002916312.1
Coordinates 878905..879171 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FTO11_RS04400 (FTO11_004400) 874061..875494 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
FTO11_RS04405 (FTO11_004405) 875613..876341 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
FTO11_RS04410 (FTO11_004410) 876391..876702 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
FTO11_RS04415 (FTO11_004415) 876866..877525 + 660 WP_002916317.1 hemolysin III family protein -
FTO11_RS04420 (FTO11_004420) 877676..878659 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
FTO11_RS04425 (FTO11_004425) 878905..879171 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
FTO11_RS04430 (FTO11_004430) 879152..879559 + 408 WP_004144731.1 protein YgfX Toxin
FTO11_RS04435 (FTO11_004435) 879566..880087 - 522 WP_002916308.1 flavodoxin FldB -
FTO11_RS04440 (FTO11_004440) 880188..881084 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
FTO11_RS04445 (FTO11_004445) 881107..881820 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
FTO11_RS04450 (FTO11_004450) 881826..883559 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15936.69 Da        Isoelectric Point: 11.4778

>T214746 WP_004144731.1 NZ_CP082753:879152-879559 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNAE
WEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 408 bp

>T214746 NZ_CP110201:c4779082-4778771 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGATGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT214746 WP_002916312.1 NZ_CP082753:878905-879171 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT214746 NZ_CP110201:c4778770-4778480 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAACCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAGC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378E4P6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References