Detailed information of TA system TA214741

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PhRel2-ATphRel2/DUF4065(antitoxin)
• Location: 2936633..2938106
• Replicon: chromosome
• Accession: NZ_CP082363
• Organism: Bacillus badius strain NBPM-293

Toxin (Protein)

• Gene name: phRel2
• Uniprot ID: A0A837YMY3
• Locus tag: K7T73_RS15350
• Protein ID: WP_041102062.1
• Coordinates: 2937384..2938106 (-)
• Length: 241 a.a.

Antitoxin (Protein)

• Gene name: ATphRel2
• Uniprot ID: -
• Locus tag: K7T73_RS15345
• Protein ID: WP_041102064.1
• Coordinates: 2936633..2937382 (-)
• Length: 250 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K7T73_RS15340 (K7T73_15315)	2935067..2935981	-	915	WP_063385288.1	DMT family transporter	-
K7T73_RS15345 (K7T73_15320)	2936633..2937382	-	750	WP_041102064.1	DUF4065 domain-containing protein	Antitoxin
K7T73_RS15350 (K7T73_15325)	2937384..2938106	-	723	WP_041102062.1	hypothetical protein	Toxin
K7T73_RS15355 (K7T73_15330)	2938295..2938522	-	228	WP_041102060.1	hypothetical protein	-
K7T73_RS15360 (K7T73_15335)	2938720..2938983	-	264	WP_041102059.1	YolD-like family protein	-
K7T73_RS15365 (K7T73_15340)	2939117..2939959	-	843	WP_082028285.1	peptidoglycan-binding protein	-
K7T73_RS15370 (K7T73_15345)	2939956..2940444	-	489	WP_041102100.1	phage holin family protein	-
K7T73_RS15375 (K7T73_15350)	2940545..2941849	-	1305	WP_223661949.1	hypothetical protein	-
K7T73_RS15380 (K7T73_15355)	2941849..2942565	-	717	WP_223661950.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2936633..2991069	54436

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RelA/SpoT (109-221)

Antitoxin

• Antitoxin SocA-like, Panacea domain (113-225)

Sequences

Toxin

Protein

• Length: 241 a.a.
• Molecular weight: 28348.44 Da
• Isoelectric Point: 7.7663

>T214741 WP_041102062.1 NZ_CP082363:c2938106-2937384 [Bacillus badius]
MENSVLDIIKQDEYRSLDYSIDTVGTLIHEVIKLHKQFSEKFIELNGALCLNFKKTLVRDVVEQVDDSDTFVINQEFHSL
LNTYLRKIDQLIIDIDLEYTYNKFDFRLRVKQLESIIYKLCHYNSGKEESGRLPLNKCLNDLLGFRIMMPGFQHGCESFS
KMCQHIEKFYKIKYRNSSKGDYKATHVYFYGGSNKNFPWELQIWLPEDYMGNYESHAKHKQEYIKSAKIHKQALRSQGGV

Nucleotide

• Length: 723 bp

>T214741 NZ_CP110201:3494600-3494818 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin

Protein

• Length: 250 a.a.
• Molecular weight: 28634.60 Da
• Isoelectric Point: 5.8708

>AT214741 WP_041102064.1 NZ_CP082363:c2937382-2936633 [Bacillus badius]
VAFHFVAIMSHYHRGARIGWHYSAPDKLDKELINTFFTKVKKKCGDVHFGIHKLSTESLSWDSVVDKDEFFADVIATKEM
DTFIDYVSRDQKLSAHDVAKFLLTIIPSSHLKLQKLLYYCYAAFLERTGERLFEEPIVAYKYGPVIESVFQDFKIHGSSI
IDYQEDGEFVLSTEKNAVTPSFIKIVNSEHGIVVIDCILDVLNTYGELDPFELVEKTHQEGGPWHRVYKPGENCVLTDDL
ITQYHQYAK

Nucleotide

• Length: 750 bp

>AT214741 NZ_CP110201:3494198-3494572 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCCAATCCTGTTAGTTTGTCTTGTTAA

Structures

Toxin

• AlphaFold DB: A0A837YMY3