Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 138313..138848 Replicon plasmid pCTHL.F3a
Accession NZ_CP082361
Organism Klebsiella sp. CTHL.F3a

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag K7H21_RS28810 Protein ID WP_223035969.1
Coordinates 138561..138848 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag K7H21_RS28805 Protein ID WP_223035968.1
Coordinates 138313..138564 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K7H21_RS28790 (K7H21_28790) 134713..136851 - 2139 WP_223035967.1 AAA family ATPase -
K7H21_RS28800 (K7H21_28800) 137108..138149 + 1042 Protein_159 translesion error-prone DNA polymerase V subunit UmuC -
K7H21_RS28805 (K7H21_28805) 138313..138564 + 252 WP_223035968.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
K7H21_RS28810 (K7H21_28810) 138561..138848 + 288 WP_223035969.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K7H21_RS28815 (K7H21_28815) 138855..139031 + 177 WP_223035970.1 hypothetical protein -
K7H21_RS28820 (K7H21_28820) 139034..139282 + 249 WP_223035971.1 hypothetical protein -
K7H21_RS28825 (K7H21_28825) 140618..141685 - 1068 WP_223035972.1 hypothetical protein -
K7H21_RS28830 (K7H21_28830) 142157..142483 - 327 WP_228751089.1 plasmid partitioning/stability family protein -
K7H21_RS28835 (K7H21_28835) 142487..142948 - 462 WP_227509734.1 plasmid segregation protein ParM -
K7H21_RS28840 (K7H21_28840) 143320..143550 - 231 WP_223035973.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..150808 150808


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11101.06 Da        Isoelectric Point: 10.2246

>T214739 WP_223035969.1 NZ_CP082361:138561-138848 [Klebsiella sp. CTHL.F3a]
MTYTVKFREDALKEWQKLDKAIQQQFAKKLKKCCDEPHIPSAKLRGIKDCYKIKLRASGFRLVYQVIDDQLIIAVVAVGK
RERSDVYNLASERVR

Download         Length: 288 bp

>T214739 NZ_CP110201:2105030-2105133 [Salmonella enterica subsp. enterica serovar Typhimurium]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9233.52 Da        Isoelectric Point: 3.9507

>AT214739 WP_223035968.1 NZ_CP082361:138313-138564 [Klebsiella sp. CTHL.F3a]
MPNMILSDTSASISELKKNPMATVSAGDGFPVAILNRNQPAFYCIPAELYEKMLDALDDQELAKLVQERSNQQLLDVDLD
TYL

Download         Length: 252 bp

>AT214739 NZ_CP110201:c2105135-2104990 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References