Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 14495..15299 Replicon plasmid pCTHL.F3a
Accession NZ_CP082361
Organism Klebsiella sp. CTHL.F3a

Toxin (Protein)


Gene name KacT Uniprot ID -
Locus tag K7H21_RS28110 Protein ID WP_211811657.1
Coordinates 14495..15022 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID -
Locus tag K7H21_RS28115 Protein ID WP_048264996.1
Coordinates 15030..15299 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K7H21_RS28090 (K7H21_28090) 10164..10421 - 258 WP_049141472.1 hypothetical protein -
K7H21_RS29125 11167..11580 + 414 Protein_11 CSS-motif domain-containing protein -
K7H21_RS29130 11644..12480 + 837 WP_228751099.1 EAL domain-containing protein -
K7H21_RS28100 (K7H21_28100) 12679..12852 + 174 WP_065366343.1 addiction module toxin, GnsA/GnsB family -
K7H21_RS29135 12948..13058 + 111 Protein_14 terminase small subunit -
K7H21_RS28105 (K7H21_28105) 13548..14411 - 864 WP_211811656.1 hypothetical protein -
K7H21_RS28110 (K7H21_28110) 14495..15022 - 528 WP_211811657.1 GNAT family N-acetyltransferase Toxin
K7H21_RS28115 (K7H21_28115) 15030..15299 - 270 WP_048264996.1 DUF1778 domain-containing protein Antitoxin
K7H21_RS28120 (K7H21_28120) 15775..15864 + 90 Protein_18 transposase -
K7H21_RS28125 (K7H21_28125) 15874..16302 - 429 Protein_19 transposase -
K7H21_RS28130 (K7H21_28130) 16576..17406 + 831 WP_228751091.1 hypothetical protein -
K7H21_RS28135 (K7H21_28135) 17579..17857 - 279 WP_223035984.1 hypothetical protein -
K7H21_RS28140 (K7H21_28140) 17857..18219 - 363 WP_223036022.1 hypothetical protein -
K7H21_RS28145 (K7H21_28145) 18263..18754 - 492 WP_223035985.1 DNA-binding protein -
K7H21_RS28150 (K7H21_28150) 18785..19351 - 567 WP_223035986.1 hypothetical protein -
K7H21_RS28155 (K7H21_28155) 19348..19611 - 264 WP_223035987.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..150808 150808


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(54-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 20118.15 Da        Isoelectric Point: 5.7389

>T214738 WP_211811657.1 NZ_CP082361:c15022-14495 [Klebsiella sp. CTHL.F3a]
VMQELVIEMINDEFDYDIGEFDCGEETLNIFLKDHLKRQHDGQILKGYVLVTKEQKPKLLGYYTLSGSCFERKMLPSKTQ
QRKIPYQNAPSITLGRLAIDKSIQGQGWGELLVTHAMNVVWDASKAVGIYGLFVEALNDKAKRFYTRLDFIQLVGENSNL
LFYPTKSIEKIFTEE

Download         Length: 528 bp

>T214738 NZ_CP110201:c1028418-1027891 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATACGATGTGCCGGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGTGGCGTAGCCCTACTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10148.65 Da        Isoelectric Point: 10.1733

>AT214738 WP_048264996.1 NZ_CP082361:c15299-15030 [Klebsiella sp. CTHL.F3a]
MSALRKQRIDLRLTDDDKSLIEEAAAMSNQTITQFVVASASERAAEVIEQHRRMVLNEESWNLVMDAIANPAAPNERLKR
AAKRLQKMR

Download         Length: 270 bp

>AT214738 NZ_CP110201:c1028705-1028415 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGGCTGTCGTTACGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACATACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGCGATACTAAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCCGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References