Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4575950..4576569 Replicon chromosome
Accession NZ_CP082360
Organism Klebsiella sp. CTHL.F3a

Toxin (Protein)


Gene name Hha Uniprot ID H3N9D8
Locus tag K7H21_RS21520 Protein ID WP_004099646.1
Coordinates 4576351..4576569 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID H3N7X7
Locus tag K7H21_RS21515 Protein ID WP_004129911.1
Coordinates 4575950..4576324 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K7H21_RS21505 (K7H21_21505) 4571120..4572313 + 1194 WP_004129915.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
K7H21_RS21510 (K7H21_21510) 4572336..4575482 + 3147 WP_004129913.1 multidrug efflux RND transporter permease subunit AcrB -
K7H21_RS21515 (K7H21_21515) 4575950..4576324 + 375 WP_004129911.1 Hha toxicity modulator TomB Antitoxin
K7H21_RS21520 (K7H21_21520) 4576351..4576569 + 219 WP_004099646.1 HHA domain-containing protein Toxin
K7H21_RS21525 (K7H21_21525) 4576731..4577297 + 567 WP_049114562.1 maltose O-acetyltransferase -
K7H21_RS29080 4577269..4577403 - 135 WP_224326009.1 hypothetical protein -
K7H21_RS21530 (K7H21_21530) 4577424..4577894 + 471 WP_004129906.1 YlaC family protein -
K7H21_RS21535 (K7H21_21535) 4577869..4579323 - 1455 WP_223035353.1 PLP-dependent aminotransferase family protein -
K7H21_RS21540 (K7H21_21540) 4579423..4580121 + 699 WP_049114564.1 GNAT family protein -
K7H21_RS21545 (K7H21_21545) 4580118..4580258 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
K7H21_RS21550 (K7H21_21550) 4580258..4580521 - 264 WP_004129897.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8640.05 Da        Isoelectric Point: 8.9008

>T214736 WP_004099646.1 NZ_CP082360:4576351-4576569 [Klebsiella sp. CTHL.F3a]
MSDKTLTKIDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPPSVWKFIR

Download         Length: 219 bp

>T214736 NZ_CP110201:870421-870834 [Salmonella enterica subsp. enterica serovar Typhimurium]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14350.09 Da        Isoelectric Point: 4.8989

>AT214736 WP_004129911.1 NZ_CP082360:4575950-4576324 [Klebsiella sp. CTHL.F3a]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIAAFALNYKIKYAEDNKLITQIDEYL
DDTFVLFSNYGINSADLQKWRKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT214736 NZ_CP110201:870174-870440 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3H713

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3HD25

References