Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4451063..4451868 Replicon chromosome
Accession NZ_CP082360
Organism Klebsiella sp. CTHL.F3a

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag K7H21_RS20910 Protein ID WP_142983382.1
Coordinates 4451063..4451452 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag K7H21_RS20915 Protein ID WP_117042590.1
Coordinates 4451509..4451868 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K7H21_RS20895 (K7H21_20895) 4447306..4448511 - 1206 WP_004130090.1 MFS transporter -
K7H21_RS20900 (K7H21_20900) 4448911..4449525 - 615 WP_049115897.1 FMN-binding negative transcriptional regulator -
K7H21_RS29070 4449860..4450000 + 141 Protein_4119 integrase -
K7H21_RS20905 (K7H21_20905) 4450139..4450984 - 846 WP_142983383.1 DUF4942 domain-containing protein -
K7H21_RS20910 (K7H21_20910) 4451063..4451452 - 390 WP_142983382.1 TA system toxin CbtA family protein Toxin
K7H21_RS20915 (K7H21_20915) 4451509..4451868 - 360 WP_117042590.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
K7H21_RS20920 (K7H21_20920) 4451893..4452114 - 222 WP_117042589.1 DUF987 domain-containing protein -
K7H21_RS20925 (K7H21_20925) 4452128..4452607 - 480 WP_047724681.1 DNA repair protein RadC -
K7H21_RS20930 (K7H21_20930) 4452619..4453062 - 444 WP_142983381.1 antirestriction protein -
K7H21_RS20935 (K7H21_20935) 4453142..4453372 - 231 WP_014837276.1 DUF905 domain-containing protein -
K7H21_RS20940 (K7H21_20940) 4453396..4454220 - 825 WP_142983380.1 DUF932 domain-containing protein -
K7H21_RS20945 (K7H21_20945) 4454761..4455393 + 633 WP_142983379.1 inovirus Gp2 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-110)

Antitoxin

Antitoxin CbeA

(15-114)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14356.50 Da        Isoelectric Point: 8.2891

>T214735 WP_142983382.1 NZ_CP082360:c4451452-4451063 [Klebsiella sp. CTHL.F3a]
MQTKSSPLMRAASSCPSPVGVWQTLLTCLLEHHYGLTLNDTPFIDEQVIQQHIDAGISLADALNFIVEKYELVRTDRPGF
SIREQSPFITSIDILRARKATGLMNCGTYKDVTAITRGLHRQVSTPGKR

Download         Length: 390 bp

>T214735 NZ_CP110201:365061-365336 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGGGGCAAAGGGAAATTGAATATTCGGGACAGTTCCAGAAAGATGTAAAACGGGCACAAAAGCGTCATAAGGATGTCGG
CAAACTTAAAACACTTATGACGCTTCTGATTCACCACCCTTTTCCCCTTCCTGCCATTTATAAAGATCACCCGTTACAAG
GTTCATATAGCGGATACCGGGATGCCCATATTGAGCCTGACTGGATTCTTATTTATAAGATAACGGATGAATGCCTGCGA
TTTGAACGAACAGGAACGCATGCCGATTTATTTTAA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13328.27 Da        Isoelectric Point: 7.3727

>AT214735 WP_117042590.1 NZ_CP082360:c4451868-4451509 [Klebsiella sp. CTHL.F3a]
MSKKTTITTHDISEPWWGLRRSVSPCFGARLVQEGNRLHYLADRANFNGQFCDADLRHLDQAFPVLMKQLELMLTSGELN
PRHQHLVTLYAKGLTCEADTLGSHGYVCIAIYPTPVATA

Download         Length: 360 bp

>AT214735 NZ_CP110201:364798-365058 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGGCTGCAAATGCGCTTGTTCGTGCCCGTATCGACGAAACGCTGAAGGACCAGGCGGCAGATGTCCTGGCTGAAATGGG
GTTAACCATTTCTGATTTGATACGGATTACACTGACTAAAGTTGCGCGTGAAAAGGCATTGCCTTTTGATTTGCGCATAC
CCAATGAGTTAACGTCCCGAACGATAGAAAATAGCGAAGCTGGCGTTGATATTCATAAAGCCAAAGATGCTGATGATTTG
TTTGACCAGTTAGGGATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References