Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 935868..936672 Replicon chromosome
Accession NZ_CP082360
Organism Klebsiella sp. CTHL.F3a

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag K7H21_RS04505 Protein ID WP_223035623.1
Coordinates 936283..936672 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag K7H21_RS04500 Protein ID WP_223035622.1
Coordinates 935868..936227 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K7H21_RS04465 (K7H21_04465) 930941..931156 - 216 WP_172754607.1 AlpA family transcriptional regulator -
K7H21_RS04470 (K7H21_04470) 931269..931913 - 645 WP_228751064.1 inovirus Gp2 family protein -
K7H21_RS04475 (K7H21_04475) 932536..933522 + 987 WP_172754592.1 hypothetical protein -
K7H21_RS04480 (K7H21_04480) 933813..934635 + 823 Protein_879 DUF932 domain-containing protein -
K7H21_RS04485 (K7H21_04485) 934668..935117 + 450 WP_223035621.1 antirestriction protein -
K7H21_RS04490 (K7H21_04490) 935129..935608 + 480 WP_196550769.1 DNA repair protein RadC -
K7H21_RS04495 (K7H21_04495) 935622..935843 + 222 WP_108704385.1 DUF987 family protein -
K7H21_RS04500 (K7H21_04500) 935868..936227 + 360 WP_223035622.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
K7H21_RS04505 (K7H21_04505) 936283..936672 + 390 WP_223035623.1 TA system toxin CbtA family protein Toxin
K7H21_RS04510 (K7H21_04510) 936759..937610 + 852 WP_223035624.1 DUF4942 domain-containing protein -
K7H21_RS04515 (K7H21_04515) 938008..938358 + 351 WP_004124874.1 transcriptional regulator -
K7H21_RS04520 (K7H21_04520) 938411..939703 + 1293 WP_004124871.1 arsenite efflux transporter membrane subunit ArsB -
K7H21_RS04525 (K7H21_04525) 939713..940138 + 426 WP_087828524.1 glutaredoxin-dependent arsenate reductase -
K7H21_RS28890 940232..940315 - 84 Protein_889 hypothetical protein -
K7H21_RS04535 (K7H21_04535) 940339..940860 + 522 WP_049114950.1 AAA family ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-111)

Antitoxin

Antitoxin CbeA

(16-114)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14415.45 Da        Isoelectric Point: 9.5904

>T214724 WP_223035623.1 NZ_CP082360:936283-936672 [Klebsiella sp. CTHL.F3a]
MQTKSSPFMRAASSRPSPVGVWQTLLTSLLEHHYGLTLNDTPFSDEQVIQQHIEAGISLADALNFIVEKYELVRIDRPGF
SIMEQSPFITPIDILRARKATGLMNRGTYKEVTAITRGQQPQANTSGKR

Download         Length: 390 bp

>T214724 NZ_CP110198:2104830-2104933 [Salmonella enterica subsp. enterica serovar Typhimurium]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13466.26 Da        Isoelectric Point: 6.3648

>AT214724 WP_223035622.1 NZ_CP082360:935868-936227 [Klebsiella sp. CTHL.F3a]
MSKNTTITTHDISELWWGLRRSVSPCFGARLVQEGNRLHYLADRANFDGQFCDADLHHLDQSFPVLMKQLELMLTSGELN
PRHQHCVTLYAKGLTCEADTLGSHGYVYIAIYPTPVTTE

Download         Length: 360 bp

>AT214724 NZ_CP110198:c2104935-2104790 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References