Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 892310..892967 Replicon chromosome
Accession NZ_CP082360
Organism Klebsiella sp. CTHL.F3a

Toxin (Protein)


Gene name cptA Uniprot ID H3N294
Locus tag K7H21_RS04265 Protein ID WP_004124948.1
Coordinates 892557..892967 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID H3N295
Locus tag K7H21_RS04260 Protein ID WP_004124953.1
Coordinates 892310..892576 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K7H21_RS04245 (K7H21_04245) 887565..887990 - 426 WP_004124962.1 PTS sugar transporter subunit IIA -
K7H21_RS04250 (K7H21_04250) 888111..890909 - 2799 WP_004124960.1 transcriptional regulator DagR -
K7H21_RS04255 (K7H21_04255) 891082..892065 - 984 WP_049122979.1 tRNA-modifying protein YgfZ -
K7H21_RS04260 (K7H21_04260) 892310..892576 + 267 WP_004124953.1 FAD assembly factor SdhE Antitoxin
K7H21_RS04265 (K7H21_04265) 892557..892967 + 411 WP_004124948.1 protein YgfX Toxin
K7H21_RS04270 (K7H21_04270) 892976..893497 - 522 WP_004124946.1 flavodoxin FldB -
K7H21_RS04275 (K7H21_04275) 893619..894515 + 897 WP_004124942.1 site-specific tyrosine recombinase XerD -
K7H21_RS04280 (K7H21_04280) 894538..895251 + 714 WP_142471602.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
K7H21_RS04285 (K7H21_04285) 895257..896990 + 1734 WP_004124937.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16089.88 Da        Isoelectric Point: 10.9455

>T214723 WP_004124948.1 NZ_CP082360:892557-892967 [Klebsiella sp. CTHL.F3a]
VVLWQSDLRISWRAQWFSLLMHGVVAALVLVLPWPLSYTPLWLILLSLVVFDCVRSQRRIHARQGEIKLLIDSRLRWQKA
EWDIIGTPWVINSGMLLRLRNTENQRTQHLWVAADSMDAGEWRDLRRLVLQKPTQE

Download         Length: 411 bp

>T214723 NZ_CP110198:c1028218-1027691 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATACGATGTGCCGGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGTGGCGTAGCCCTACTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10411.88 Da        Isoelectric Point: 5.1296

>AT214723 WP_004124953.1 NZ_CP082360:892310-892576 [Klebsiella sp. CTHL.F3a]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDGDKALFIRLLENDDPDLFNWLMNHGEPADAELQRMVKLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT214723 NZ_CP110198:c1028505-1028215 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGGCTGTCGTTACGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACATACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGCGATACTAAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCCGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB H3N294

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3H3L9

References