Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 316179..316774 Replicon chromosome
Accession NZ_CP082355
Organism Escherichia coli strain VCSW5

Toxin (Protein)


Gene name doc Uniprot ID D6JG31
Locus tag K7X33_RS01410 Protein ID WP_000155159.1
Coordinates 316397..316774 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID D6JG32
Locus tag K7X33_RS01405 Protein ID WP_000557315.1
Coordinates 316179..316400 (+) Length 74 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K7X33_RS01380 (311255) 311255..312364 + 1110 WP_001309015.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
K7X33_RS01385 (312412) 312412..313338 + 927 WP_001295097.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
K7X33_RS01390 (313335) 313335..314612 + 1278 WP_000803824.1 branched chain amino acid ABC transporter permease LivM -
K7X33_RS01395 (314609) 314609..315376 + 768 WP_000082101.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
K7X33_RS01400 (315378) 315378..316091 + 714 WP_000416898.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
K7X33_RS01405 (316179) 316179..316400 + 222 WP_000557315.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
K7X33_RS01410 (316397) 316397..316774 + 378 WP_000155159.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
K7X33_RS01415 (316983) 316983..318299 + 1317 WP_000803191.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
K7X33_RS01420 (318475) 318475..319362 + 888 WP_000099289.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
K7X33_RS01425 (319359) 319359..320204 + 846 WP_000572183.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
K7X33_RS01430 (320206) 320206..321276 + 1071 WP_000907829.1 sn-glycerol 3-phosphate ABC transporter ATP binding protein UgpC -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 313335..322016 8681


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(27-86)

Antitoxin

(1-53)


Sequences


Toxin        


Download         Length: 126 a.a.        Molecular weight: 13964.25 Da        Isoelectric Point: 6.7263

>T214669 WP_000155159.1 NZ_CP082355:316397-316774 [Escherichia coli]
MTIQFISAEEIIYFHDKLLSVTPGVTGMSDPGRAEALLYRVLNKYEYEGVSDLWLLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILAANPEFVELTVDVAAGKVSLEDIVTRLRQRGT

Download         Length: 378 bp

>T214669 NZ_CP110170:798139-798549 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8103.24 Da        Isoelectric Point: 6.2168

>AT214669 WP_000557315.1 NZ_CP082355:316179-316400 [Escherichia coli]
MHTMNYSEARQNLALVLETAATGTPVTITRRGHKAAVIISAEEFERYQKAKLDAEFDAIMAIHGSEIKELADK

Download         Length: 222 bp

>AT214669 NZ_CP110170:797892-798158 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB D6JG31


Antitoxin

Source ID Structure
AlphaFold DB D6JG32

References