Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 138958..139465 Replicon plasmid pVCSW10.1
Accession NZ_CP082352
Organism Providencia rettgeri strain VCSW10

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag K7H99_RS21015 Protein ID WP_222960756.1
Coordinates 139190..139465 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag K7H99_RS21010 Protein ID WP_282565750.1
Coordinates 138958..139203 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K7H99_RS22310 134539..134664 + 126 Protein_137 IS3 family transposase -
K7H99_RS22475 135705..135881 - 177 WP_282565749.1 hypothetical protein -
K7H99_RS20990 (K7H99_20990) 136057..136503 + 447 WP_222960754.1 hypothetical protein -
K7H99_RS21000 (K7H99_21000) 136635..136975 - 341 Protein_140 transposase -
K7H99_RS21005 (K7H99_21005) 137872..138045 + 174 Protein_141 transposase -
K7H99_RS21010 (K7H99_21010) 138958..139203 + 246 WP_282565750.1 DUF6290 family protein Antitoxin
K7H99_RS21015 (K7H99_21015) 139190..139465 + 276 WP_222960756.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K7H99_RS21020 (K7H99_21020) 140526..140831 - 306 WP_222960759.1 nitroreductase family protein -
K7H99_RS21025 (K7H99_21025) 140835..141179 - 345 WP_222960761.1 nitroreductase family protein -
K7H99_RS21030 (K7H99_21030) 142148..143382 - 1235 Protein_146 IS30 family transposase -
K7H99_RS21035 (K7H99_21035) 143849..144079 - 231 WP_222960777.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..243713 243713
- flank IS/Tn - - 136706..136975 269


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-88)

Antitoxin

Protein of unknown function DUF6290

(7-70)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10957.89 Da        Isoelectric Point: 10.3778

>T214665 WP_222960756.1 NZ_CP082352:139190-139465 [Providencia rettgeri]
MPHYRIEYTKRFQKELKKLGRCHQKIIQSYIEKNIDNSINPRLIGKILKGDKAEFIRYRIGDYRLIATIEDERLVILALS
IGHRKDVYKHF

Download         Length: 276 bp

>T214665 NZ_CP110168:168133-168549 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGTGGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCT
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACCGCCATTGC
CGGACACGCCATCGCGGCGGGCGCCATCCTGGTGACGAATAATACAAGAGAGTTTGAGCGGGTGCCGGGTCTGGTTCTGG
AAGACTGGGTTAAGTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9188.30 Da        Isoelectric Point: 4.2182

>AT214665 WP_282565750.1 NZ_CP082352:138958-139203 [Providencia rettgeri]
MRKNLTKAIRLNNEELSLFESYANAKGLTFSELCKSAIIEKIEDEIDLKLAEEAYEEYLNDNETLSHKDIFDPLGNYASL

Download         Length: 246 bp

>AT214665 NZ_CP110168:167906-168136 [Klebsiella pneumoniae]
ATGCGCACAGTATCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGATCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGACGAAGGACGCTTTGATCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References