Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 4205943..4206489 Replicon chromosome
Accession NZ_CP082351
Organism Providencia rettgeri strain VCSW10

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag K7H99_RS19480 Protein ID WP_222960022.1
Coordinates 4206208..4206489 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag K7H99_RS19475 Protein ID WP_102140619.1
Coordinates 4205943..4206227 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K7H99_RS19450 (K7H99_19450) 4201018..4201995 - 978 WP_004265237.1 6-phosphofructokinase -
K7H99_RS19455 (K7H99_19455) 4202401..4203345 - 945 WP_109912960.1 phosphatidate cytidylyltransferase -
K7H99_RS19460 (K7H99_19460) 4203342..4203983 - 642 WP_222960021.1 lysophospholipid acyltransferase family protein -
K7H99_RS19465 (K7H99_19465) 4204221..4204973 - 753 WP_004907010.1 M48 family metallopeptidase -
K7H99_RS19470 (K7H99_19470) 4205200..4205781 - 582 WP_004907006.1 HutD family protein -
K7H99_RS19475 (K7H99_19475) 4205943..4206227 + 285 WP_102140619.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
K7H99_RS19480 (K7H99_19480) 4206208..4206489 + 282 WP_222960022.1 type II toxin-antitoxin system YafQ family toxin Toxin
K7H99_RS19485 (K7H99_19485) 4206886..4207416 + 531 WP_222960023.1 hypothetical protein -
K7H99_RS19490 (K7H99_19490) 4207447..4207698 - 252 WP_222960024.1 ogr/Delta-like zinc finger family protein -
K7H99_RS19495 (K7H99_19495) 4207748..4208872 - 1125 WP_222960025.1 phage late control D family protein -
K7H99_RS19500 (K7H99_19500) 4209028..4210215 + 1188 WP_222960026.1 phage tail sheath subtilisin-like domain-containing protein -
K7H99_RS19505 (K7H99_19505) 4210219..4210731 + 513 WP_222960027.1 phage major tail tube protein -
K7H99_RS19510 (K7H99_19510) 4210788..4211087 + 300 WP_222960034.1 phage tail assembly protein -
K7H99_RS22265 4211174..4211239 + 66 WP_230082178.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-92)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(9-84)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11039.92 Da        Isoelectric Point: 9.4858

>T214664 WP_222960022.1 NZ_CP082351:4206208-4206489 [Providencia rettgeri]
MLKIRVKSQFKKDLKKSLSDKKRNTQLLKELIDNHLCITGSVPAEYLPHPLKKNWRPCYEYHIQPDFLLIWDINYQTNEI
ILVRCGSHSELFG

Download         Length: 282 bp

>T214664 NZ_CP110168:55933-56403 [Klebsiella pneumoniae]
GTGATCCTCTACAGGCTGACGAAAACAAAGTATCTTTCTACGGCCTGGACCGGATATGGTGCGAAAGAGGCTGGTGGGCG
CTGGAATAGCGTGGGGGTGTCAATGGTATATGTCTCCGAAACAGCATCACTAACGATGCTGGAGACGCTGGTACACCTGC
ATGCGGCACAGATAATGGACTCTTTCACGCTACTGAGTATCGATGTGCCTGATGAACTGATCCAAAGCGCAAACATGGAT
GAATTACCGGACAACTGGGCTGATGAGGATGCGCCTCAGGAACTGGCTGATTACGGAGATGCCTGGTCATTTACCAGGAG
CTCGGTTGCACTGCGTGTTCCCTCAGCCTTATCGCCGGTAGAGTTCAATTATCTGTTAAATCCTGAGCACCCTGAGTTTT
ACGGGATCGTGCAGAAGGCTCAACAGATACCGTTCCGGTTTGATAGTCGTCTTAAACCTGACAGGAAGTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10420.71 Da        Isoelectric Point: 4.6412

>AT214664 WP_102140619.1 NZ_CP082351:4205943-4206227 [Providencia rettgeri]
MASTQHKTDIVRARIEPKVRENAEAVLSELGISMSDAIRIFVKQISLRQAFPIELKTPNSITLEAINAPTTDETFDSAED
LFSQVSKSDAENSR

Download         Length: 285 bp

>AT214664 NZ_CP110168:55493-55936 [Klebsiella pneumoniae]
ATGAAAACTTTTAGTTTGTCCTCAAGTCCAGCCAGACCACAGCGCCTCTGGCAGGTTGCCGGGTTAAATAATGCTGATGG
TGTAGCGCTCCTGGGCCAAATCAATGAAGGCCTGGACGGGAAGGTGGTGAACCGGATCACTGACTGGGCCAGAATAACCC
AGAATGACCTGAGAAAAATGTCCGGTATCCCGTCAACCACATTTAGCCGCAGTGTGAAGGCACGTTTTAACCCGGAACAA
AGTGAACGTCTGGTACGGATTATCCGCGTTATTGATCGGGCGGTAGATTTGTTTGAAGGCGACAGGGAAGCCGCACAGAA
GTGGTTGAACGAACCTAACCGGGCATTGAGCTGGAAAGTGCCAGCAGACCTGATGGCATCCGAAACTGGAGCCTATGAGG
TCATTAAGCTGATTACGCGTCTGGAGCATGGGGTGTACTCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References