Detailed information of TA system TA214663

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 2351616..2352532
• Replicon: chromosome
• Accession: NZ_CP082351
• Organism: Providencia rettgeri strain VCSW10

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: K7H99_RS10635
• Protein ID: WP_109912200.1
• Coordinates: 2352074..2352532 (+)
• Length: 153 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A6G6PJY5
• Locus tag: K7H99_RS10630
• Protein ID: WP_004910826.1
• Coordinates: 2351616..2352077 (+)
• Length: 154 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K7H99_RS10600 (K7H99_10600)	2347052..2347525	-	474	WP_110731925.1	NUDIX domain-containing protein	-
K7H99_RS10605 (K7H99_10605)	2347818..2348459	-	642	WP_004910832.1	leucine efflux protein LeuE	-
K7H99_RS10610 (K7H99_10610)	2348943..2349797	+	855	WP_004910830.1	AraC family transcriptional regulator	-
K7H99_RS10615 (K7H99_10615)	2349856..2350557	+	702	WP_004910829.1	AzlC family ABC transporter permease	-
K7H99_RS10620 (K7H99_10620)	2350554..2350868	+	315	WP_004910828.1	AzlD domain-containing protein	-
K7H99_RS10625 (K7H99_10625)	2351060..2351527	+	468	WP_109912201.1	DUF1456 family protein	-
K7H99_RS10630 (K7H99_10630)	2351616..2352077	+	462	WP_004910826.1	DUF2384 domain-containing protein	Antitoxin
K7H99_RS10635 (K7H99_10635)	2352074..2352532	+	459	WP_109912200.1	RES domain-containing protein	Toxin
K7H99_RS10640 (K7H99_10640)	2352533..2353423	-	891	WP_109912199.1	LysR family transcriptional regulator	-
K7H99_RS10645 (K7H99_10645)	2353469..2354428	-	960	WP_109912198.1	acetyl-CoA carboxylase carboxyl transferase subunit alpha	-
K7H99_RS10650 (K7H99_10650)	2354534..2354956	-	423	WP_004910820.1	helix-turn-helix domain-containing protein	-
K7H99_RS10655 (K7H99_10655)	2354987..2355514	-	528	WP_004910818.1	GNAT family N-acetyltransferase	-
K7H99_RS10660 (K7H99_10660)	2355531..2356997	-	1467	WP_109912197.1	AMP nucleosidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-146)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (99-150)

Sequences

Toxin

Protein

• Length: 153 a.a.
• Molecular weight: 17178.73 Da
• Isoelectric Point: 6.2048

>T214663 WP_109912200.1 NZ_CP082351:2352074-2352532 [Providencia rettgeri]
MILYRLVKSSFIHDAWSGQGAMLYGGRWNHKGTPAVYTSTSISLATLEILVHINQDLLLNQFSLLSIDINDRYVMKLSLD
HLPTDWQQDPAPTSTMDIGTTWLNNQDSLVLLIPSCIIPYEYNAIINPLHPQFQKAIHTVKPLDFSVDSRLA

Nucleotide

• Length: 459 bp

>T214663 NZ_CP110167:c5268084-5267701 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCATCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin

Protein

• Length: 154 a.a.
• Molecular weight: 17060.54 Da
• Isoelectric Point: 9.9140

>AT214663 WP_004910826.1 NZ_CP082351:2351616-2352077 [Providencia rettgeri]
MRNYIPTTPLQPTASSFKPLWRHVGLPAERGIELTHFLRQGLSVSVLDNIQEWSGMSKTELLRISGINERNIARRKNAGQ
PLNADESERIARLVRVFDAAVRLFNGDKHAAGDWLNHPVKGLGHLRPIELIATESGAIEVIDLIGRIEHGVFS

Nucleotide

• Length: 462 bp

>AT214663 NZ_CP110167:c5268326-5268084 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Structures

Antitoxin

• AlphaFold DB: A0A6G6PJY5