Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1467734..1468391 Replicon chromosome
Accession NZ_CP082351
Organism Providencia rettgeri strain VCSW10

Toxin (Protein)


Gene name cptA Uniprot ID A0A6G6PHM2
Locus tag K7H99_RS06440 Protein ID WP_042851636.1
Coordinates 1467981..1468391 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A6G6PHM9
Locus tag K7H99_RS06435 Protein ID WP_004913039.1
Coordinates 1467734..1468000 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K7H99_RS06420 (K7H99_06420) 1464730..1465626 - 897 WP_164528562.1 hypothetical protein -
K7H99_RS06425 (K7H99_06425) 1465871..1466491 - 621 WP_109912916.1 HD domain-containing protein -
K7H99_RS06430 (K7H99_06430) 1466503..1467486 - 984 WP_110732097.1 tRNA-modifying protein YgfZ -
K7H99_RS06435 (K7H99_06435) 1467734..1468000 + 267 WP_004913039.1 FAD assembly factor SdhE Antitoxin
K7H99_RS06440 (K7H99_06440) 1467981..1468391 + 411 WP_042851636.1 protein YgfX Toxin
K7H99_RS06445 (K7H99_06445) 1468481..1468999 - 519 WP_004913034.1 flavodoxin FldB -
K7H99_RS06450 (K7H99_06450) 1469117..1470019 + 903 WP_109912915.1 site-specific tyrosine recombinase XerD -
K7H99_RS06455 (K7H99_06455) 1470041..1470745 + 705 WP_109912946.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
K7H99_RS06460 (K7H99_06460) 1470755..1472488 + 1734 WP_110732096.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-133)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15612.59 Da        Isoelectric Point: 10.7733

>T214662 WP_042851636.1 NZ_CP082351:1467981-1468391 [Providencia rettgeri]
VVLWKSNLSISWKTQLFSTCVHGVIGMFLLLTPWSPGNSMIWLPLLVVVVASWAKSQKNISKIKGVAVLVNGNKLQWKKN
EWRILKAPWLTRYGILLTLEALQGKPQKIHLWVAKDALSEENWRNLNQLLLQYPDI

Download         Length: 411 bp

>T214662 NZ_CP110167:c4926480-4925563 [Klebsiella pneumoniae]
ATGGATATACAGGCGCCTTATTATCGGCAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACTGCCATCAATCTCTTTATCCGCGATTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCACCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGTGTA
TTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAATCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTATCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10674.24 Da        Isoelectric Point: 4.8780

>AT214662 WP_004913039.1 NZ_CP082351:1467734-1468000 [Providencia rettgeri]
MDIENKARIHWACRRGMRELDISIMPFFEYEYDNLTTQDKQVFVRLLECADPDLFNWLMNHGRPDDDELFRMIKLIQEKN
KNRGPVEI

Download         Length: 267 bp

>AT214662 NZ_CP110167:c4927244-4926486 [Klebsiella pneumoniae]
ATGGCAACAAAATTAAACTGGCTGCTGCAAAACAGCGCTCCCGGAGATGTGATCCTTCAGTCCTGGTTAAGCCAGCATGC
CATCTCTCCCTCTCTGGCCTTTAAATATGCGCAAAGTGGCTGGTTAAAAAAAAGAGGCAACGGCGTATATGCGCGTGCGG
GACGTGAGCCGGAGTGGAACGATGCATTAGCATGTTTGCAAAATCAGCTTGCCGCTCCGGTGTATGTTGCGGGGCTCAGT
AGCTTAGTCTGGCAGGGCCGTTCACACTATCTACAGCTAAAACAAAACCAGTGCTGGCTTAGTGTGGAAAATAAAGCGCT
GCTGCCGAAATGGTTCAGGGAATTCCCGGGTGTGGAGTGGATAGTCATATCGGGGAAAAAACTGCCGGTGCTGGATGATA
GATACCGTGTAACGCTTGATATAAAAGGGAAAAAACTCATCGGCAGTGCGCCAGAACTGGCTGCTTACGAGTTGCTGAGC
GCGGTGCCGGGGACCCTCTCATTTAACCACGCTGCAGAGCTTTTCCAGGGGCTGGTTAATCTTAATCCTCGTAAAGTAGA
GTATCTTCTTTCCGTCAGCCAGTCCGTGCAGGCCAAGCGTTTGTATCTCTTCTTCGCCAGTTTTTACGAGCATGGCTGGC
TCAAACGAATCGATAGCCAAAAAATCGATCTGGGAGCGGGCAAGCGGCAAATCGTGGAAAATGGAAAGTTCAATGCTCAA
TACCAAATCACAGTGCCTGAACGCTTTCAAAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6G6PHM2

Antitoxin

Source ID Structure
AlphaFold DB A0A6G6PHM9

References