Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 863089..863734 Replicon chromosome
Accession NZ_CP082351
Organism Providencia rettgeri strain VCSW10

Toxin (Protein)


Gene name Hha Uniprot ID B6XA97
Locus tag K7H99_RS03790 Protein ID WP_004905417.1
Coordinates 863089..863292 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A6G6PGA8
Locus tag K7H99_RS03795 Protein ID WP_004914480.1
Coordinates 863366..863734 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K7H99_RS03765 (K7H99_03765) 859186..859524 + 339 WP_004905421.1 P-II family nitrogen regulator -
K7H99_RS03770 (K7H99_03770) 859574..860821 + 1248 WP_235148226.1 ammonium transporter AmtB -
K7H99_RS03775 (K7H99_03775) 860960..861829 - 870 WP_004914483.1 acyl-CoA thioesterase II -
K7H99_RS03780 (K7H99_03780) 862069..862527 + 459 WP_004914482.1 YbaY family lipoprotein -
K7H99_RS03790 (K7H99_03790) 863089..863292 - 204 WP_004905417.1 HHA domain-containing protein Toxin
K7H99_RS03795 (K7H99_03795) 863366..863734 - 369 WP_004914480.1 Hha toxicity modulator TomB Antitoxin
K7H99_RS03800 (K7H99_03800) 864257..865627 - 1371 WP_222960338.1 murein transglycosylase D -
K7H99_RS03805 (K7H99_03805) 865709..866464 - 756 WP_117162848.1 hydroxyacylglutathione hydrolase -
K7H99_RS03810 (K7H99_03810) 866505..867239 + 735 WP_109911903.1 methyltransferase domain-containing protein -
K7H99_RS03815 (K7H99_03815) 867236..867706 - 471 WP_004914473.1 ribonuclease HI -
K7H99_RS03820 (K7H99_03820) 867761..868522 + 762 WP_004914471.1 DNA polymerase III subunit epsilon -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8061.34 Da        Isoelectric Point: 6.9770

>T214661 WP_004905417.1 NZ_CP082351:c863292-863089 [Providencia rettgeri]
MTKSDYLMRLRKCTTIETLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPASVWKFVR

Download         Length: 204 bp

>T214661 NZ_CP110167:c4769019-4768735 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCTGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14106.06 Da        Isoelectric Point: 4.3849

>AT214661 WP_004914480.1 NZ_CP082351:c863734-863366 [Providencia rettgeri]
MDEYSPKRHDIAELKYLCNSLNRDAILSLQKTNTHWINDLSSPQSAALNELIEHIAAFVWRFKIKYPKENLVISLIEEYL
DETYDLFGSPVITLSEIIDWEAMNQSLVTVLDDDLKCLTSKT

Download         Length: 369 bp

>AT214661 NZ_CP110167:c4769251-4769009 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A291E6Q2

Antitoxin

Source ID Structure
AlphaFold DB A0A6G6PGA8

References