Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | parDE/RelE-RHH |
Location | 62639..63186 | Replicon | plasmid pAL.H8 |
Accession | NZ_CP082350 | ||
Organism | Escherichia coli strain AL.H8 |
Toxin (Protein)
Gene name | parE | Uniprot ID | G7QEJ9 |
Locus tag | K7H97_RS23205 | Protein ID | WP_001384452.1 |
Coordinates | 62908..63186 (+) | Length | 93 a.a. |
Antitoxin (Protein)
Gene name | parD | Uniprot ID | A0A1M1SX19 |
Locus tag | K7H97_RS23200 | Protein ID | WP_021546940.1 |
Coordinates | 62639..62908 (+) | Length | 90 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
K7H97_RS23175 (K7H97_23175) | 58073..58174 | + | 102 | WP_001326870.1 | NAD(P)-binding domain-containing protein | - |
K7H97_RS23180 (K7H97_23180) | 58200..59168 | - | 969 | WP_004099053.1 | IS5-like element IS903B family transposase | - |
K7H97_RS23485 | 59350..59478 | + | 129 | WP_001334698.1 | hypothetical protein | - |
K7H97_RS23185 (K7H97_23185) | 59767..60024 | + | 258 | WP_001333498.1 | helix-turn-helix transcriptional regulator | - |
K7H97_RS23190 (K7H97_23190) | 60099..60686 | + | 588 | WP_001333497.1 | GNAT family N-acetyltransferase | - |
K7H97_RS23195 (K7H97_23195) | 60952..61656 | - | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
K7H97_RS23200 (K7H97_23200) | 62639..62908 | + | 270 | WP_021546940.1 | type II toxin-antitoxin system antitoxin YacA | Antitoxin |
K7H97_RS23205 (K7H97_23205) | 62908..63186 | + | 279 | WP_001384452.1 | type II toxin-antitoxin system toxin YacB | Toxin |
K7H97_RS23210 (K7H97_23210) | 63232..63444 | + | 213 | Protein_56 | 3'-5' exonuclease | - |
K7H97_RS23215 (K7H97_23215) | 63539..63775 | + | 237 | WP_223417154.1 | transposase | - |
K7H97_RS23220 (K7H97_23220) | 64024..64575 | + | 552 | Protein_58 | 3'-5' exonuclease | - |
K7H97_RS23225 (K7H97_23225) | 64744..64919 | + | 176 | Protein_59 | integrase core domain-containing protein | - |
K7H97_RS23230 (K7H97_23230) | 64992..65678 | + | 687 | WP_023281065.1 | DNA-binding transcriptional regulator rspR | - |
K7H97_RS23235 (K7H97_23235) | 65775..66224 | + | 450 | Protein_61 | transposase | - |
K7H97_RS23240 (K7H97_23240) | 66474..67454 | - | 981 | WP_000019450.1 | IS5-like element ISKpn26 family transposase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | - | ugd / galF / gnd | 1..79616 | 79616 | |
- | inside | IScluster/Tn | - | - | 58200..78825 | 20625 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10762.38 Da Isoelectric Point: 8.4615
>T214660 WP_001384452.1 NZ_CP082350:62908-63186 [Escherichia coli]
MEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTAQKWP
MEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTAQKWP
Download Length: 279 bp
>T214660 NZ_CP110167:c4643469-4642936 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA
Antitoxin
Download Length: 90 a.a. Molecular weight: 10321.69 Da Isoelectric Point: 8.8725
>AT214660 WP_021546940.1 NZ_CP082350:62639-62908 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVAAGRQQLERGDVLPHDMVESSAAAWRD
EMRRKVADK
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVAAGRQQLERGDVLPHDMVESSAAAWRD
EMRRKVADK
Download Length: 270 bp
>AT214660 NZ_CP110167:c4643746-4643480 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829CL36 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A1M1SX19 |