Detailed information of TA system TA214651

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2405955..2407543
• Replicon: chromosome
• Accession: NZ_CP082349
• Organism: Escherichia coli strain AL.H8

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: K7H97_RS11890
• Protein ID: WP_094029411.1
• Coordinates: 2406221..2407543 (+)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: K7H97_RS11885
• Protein ID: WP_001296726.1
• Coordinates: 2405955..2406221 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K7H97_RS11885 (2405955)	2405955..2406221	+	267	WP_001296726.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
K7H97_RS11890 (2406221)	2406221..2407543	+	1323	WP_094029411.1	type II toxin-antitoxin system serine/threonine protein kinase toxin HipA	Toxin
K7H97_RS23395 (2407861)	2407861..2408012	+	152	Protein_2329	AraC family transcriptional regulator	-
K7H97_RS11895 (2408005)	2408005..2408451	+	447	Protein_2330	fimbria/pilus periplasmic chaperone	-
K7H97_RS11900 (2408493)	2408493..2411144	+	2652	WP_001583524.1	fimbria/pilus outer membrane usher protein	-
K7H97_RS11905 (2411158)	2411158..2411688	+	531	WP_000876784.1	fimbrial protein	-
K7H97_RS11910 (2411701)	2411701..2412204	+	504	WP_000825458.1	fimbrial protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2405955..2421430	15475

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (7-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-69)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49450.11 Da
• Isoelectric Point: 9.1203

>T214651 WP_094029411.1 NZ_CP082349:2406221-2407543 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLLPENETITRPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGRVRALAVERFDRRW
NTERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALRDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLVTAKVLRFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGSK

Nucleotide

• Length: 1323 bp

>T214651 NZ_CP110161:c87854-87438 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACAAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGTTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCC
GCGGTGGACGCCACGACGGCCATCCGGATAGCGCAGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCCATCGCGGCCGGCGCCGTCCTGGTGACGAATAATGTGAGAGAGTTTGAGCGGGTGCCGGGTCTGGTTCTGG
AAGACTGGGTTAAGTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10047.39 Da
• Isoelectric Point: 4.9632

>AT214651 WP_001296726.1 NZ_CP082349:2405955-2406221 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDTKNASPES
TEQQDLEW

Nucleotide

• Length: 267 bp

>AT214651 NZ_CP110161:c88081-87851 [Klebsiella pneumoniae]
ATGCGCACAGTATCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGATCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA