Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 2320921..2321447 | Replicon | chromosome |
| Accession | NZ_CP082349 | ||
| Organism | Escherichia coli strain AL.H8 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | K7H97_RS11420 | Protein ID | WP_000323025.1 |
| Coordinates | 2321160..2321447 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | K7H97_RS11415 | Protein ID | WP_000534858.1 |
| Coordinates | 2320921..2321160 (+) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K7H97_RS11390 (2316255) | 2316255..2316744 | + | 490 | Protein_2226 | class I SAM-dependent methyltransferase | - |
| K7H97_RS11395 (2317222) | 2317222..2317643 | + | 422 | Protein_2227 | hypothetical protein | - |
| K7H97_RS23380 (2318278) | 2318278..2318649 | + | 372 | WP_021511900.1 | helix-turn-helix domain-containing protein | - |
| K7H97_RS23385 (2318687) | 2318687..2319349 | + | 663 | Protein_2229 | ISNCY family transposase | - |
| K7H97_RS23390 (2319470) | 2319470..2319619 | + | 150 | WP_011443592.1 | protein YdfW | - |
| K7H97_RS11405 (2320056) | 2320056..2320388 | - | 333 | WP_001317460.1 | FlxA-like family protein | - |
| K7H97_RS11410 (2320591) | 2320591..2320896 | - | 306 | WP_001326990.1 | protein YdfV | - |
| K7H97_RS11415 (2320921) | 2320921..2321160 | + | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| K7H97_RS11420 (2321160) | 2321160..2321447 | + | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| K7H97_RS11425 (2321519) | 2321519..2321674 | + | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| K7H97_RS11430 (2321891) | 2321891..2322142 | + | 252 | WP_000980994.1 | protein Rem | - |
| K7H97_RS11435 (2322209) | 2322209..2322487 | + | 279 | WP_012304870.1 | hypothetical protein | - |
| K7H97_RS11440 (2322489) | 2322489..2323538 | + | 1050 | WP_001265198.1 | DUF968 domain-containing protein | - |
| K7H97_RS11445 (2323552) | 2323552..2324304 | + | 753 | WP_001047135.1 | antitermination protein | - |
| K7H97_RS11450 (2324582) | 2324582..2324671 | - | 90 | WP_120795389.1 | hypothetical protein | - |
| K7H97_RS11455 (2324726) | 2324726..2324938 | - | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| K7H97_RS11460 (2325239) | 2325239..2325454 | + | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
| K7H97_RS11465 (2325818) | 2325818..2325988 | - | 171 | WP_211180497.1 | putative zinc-binding protein YnfU | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2307649..2360692 | 53043 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T214650 WP_000323025.1 NZ_CP082349:2321160-2321447 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T214650 NZ_CP110161:22095-22406 [Klebsiella pneumoniae]
ATGCACGTAATTTCAAAAGAGCCTTTTGAGGAAGCGGCAAAGCGATATCCCAACGATTCGTTAGCCATTCGGGCATTGTA
CCGCTTAGTGCGCGAGACGGACTTCTCTTCTCCAGCTGAGATGCTAACTCTGATACCGAGCCTGGATAATTTTAAGTACA
GGAATAAGTGGTGGGTTTTAGATGTAGGGGGCAACAACTTGAGGGTTATCGCCTATATCAATTTCGTAAATAAGCGCTTC
TACGTGAAGCACATCGCAACCCACGCTGATTACGACAAGTTGACCCGCTATTACAGGGAGAACAAAGAATGA
ATGCACGTAATTTCAAAAGAGCCTTTTGAGGAAGCGGCAAAGCGATATCCCAACGATTCGTTAGCCATTCGGGCATTGTA
CCGCTTAGTGCGCGAGACGGACTTCTCTTCTCCAGCTGAGATGCTAACTCTGATACCGAGCCTGGATAATTTTAAGTACA
GGAATAAGTGGTGGGTTTTAGATGTAGGGGGCAACAACTTGAGGGTTATCGCCTATATCAATTTCGTAAATAAGCGCTTC
TACGTGAAGCACATCGCAACCCACGCTGATTACGACAAGTTGACCCGCTATTACAGGGAGAACAAAGAATGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT214650 WP_000534858.1 NZ_CP082349:2320921-2321160 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT214650 NZ_CP110161:22403-22822 [Klebsiella pneumoniae]
ATGATTACCGACACTGCAAAAGCCATTGAAGCAACCAAACAACTCGTAGCTGCCGTCCCCTTCCTAGGGGGCAGTTCTTC
CGAGAGCGATTACCGCGAAGCGATGGAGCTGGTGGATTATCTGATCGAGAACGACGACGAGAACCCACTTATTGACTTCC
TGGCGAGTAAGATTGCCGACTATGAAGATAACAGCCCTCGTTTCGCTGAGTTCAACAAAGCTATTGCTGAAATACCAGTC
GGCGTTGCACTTCTGCGAACCCTGATTGACCAGCACAAGCTGTCTTATTCAGACCTTAAGGATGAGATCGGATCTAAATC
ATTGGTCAGCCAAATCCTGTCAGGGCAGCGCTCTTTGACCATCACTCACATAAAAGCTCTTTCCGCGCGCTTCGGTGTAA
AACCTGAGTGGTTCCTATAA
ATGATTACCGACACTGCAAAAGCCATTGAAGCAACCAAACAACTCGTAGCTGCCGTCCCCTTCCTAGGGGGCAGTTCTTC
CGAGAGCGATTACCGCGAAGCGATGGAGCTGGTGGATTATCTGATCGAGAACGACGACGAGAACCCACTTATTGACTTCC
TGGCGAGTAAGATTGCCGACTATGAAGATAACAGCCCTCGTTTCGCTGAGTTCAACAAAGCTATTGCTGAAATACCAGTC
GGCGTTGCACTTCTGCGAACCCTGATTGACCAGCACAAGCTGTCTTATTCAGACCTTAAGGATGAGATCGGATCTAAATC
ATTGGTCAGCCAAATCCTGTCAGGGCAGCGCTCTTTGACCATCACTCACATAAAAGCTCTTTCCGCGCGCTTCGGTGTAA
AACCTGAGTGGTTCCTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|