21465

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 869363..869840 Replicon chromosome
Accession NC_007793
Organism Staphylococcus aureus subsp. aureus USA300 FPR3757

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag SAUSA300_RS04210 Protein ID WP_000052078.1
Coordinates 869363..869551 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag SAUSA300_RS04215 Protein ID WP_001059690.1
Coordinates 869580..869840 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAUSA300_RS04180 865404..865874 + 471 WP_000824472.1 hypothetical protein -
SAUSA300_RS04185 866215..866901 + 687 WP_001548082.1 thermonuclease family protein -
SAUSA300_RS04190 867258..867458 + 201 WP_001059082.1 cold-shock protein -
SAUSA300_RS04195 867954..868172 - 219 WP_000005886.1 hypothetical protein -
SAUSA300_RS04200 868234..868518 - 285 WP_001004395.1 hypothetical protein -
SAUSA300_RS04205 868606..869175 - 570 WP_001106654.1 hypothetical protein -
SAUSA300_RS04210 869363..869551 - 189 WP_000052078.1 hypothetical protein Toxin
SAUSA300_RS04215 869580..869840 - 261 WP_001059690.1 hypothetical protein Antitoxin
SAUSA300_RS04220 870181..870384 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
SAUSA300_RS04225 870381..870617 - 237 WP_000368687.1 hypothetical protein -
SAUSA300_RS04230 870842..871423 + 582 WP_001140686.1 phosphoglycerate mutase family protein -
SAUSA300_RS04235 871496..872113 - 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
SAUSA300_RS04240 872268..872762 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
SAUSA300_RS04245 873161..873583 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
SAUSA300_RS04250 873731..874447 + 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - selk / selq 864047..895129 31082


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(26-97)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T21465 WP_000052078.1 NC_007793:c869551-869363 [Staphylococcus aureus subsp. aureus USA300_FPR3757]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T21465 NC_007793:c869551-869363 [Staphylococcus aureus subsp. aureus USA300_FPR3757]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT21465 WP_001059690.1 NC_007793:c869840-869580 [Staphylococcus aureus subsp. aureus USA300_FPR3757]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT21465 NC_007793:c869840-869580 [Staphylococcus aureus subsp. aureus USA300_FPR3757]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References