Detailed information of TA system TA214635

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 67374..67909
• Replicon: plasmid pLsch
• Accession: NZ_CP082348
• Organism: Pantoea dispersa strain Lsch

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: K7H94_RS22400
• Protein ID: WP_222952521.1
• Coordinates: 67374..67661 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: K7H94_RS22405
• Protein ID: WP_222952522.1
• Coordinates: 67658..67909 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K7H94_RS22375 (K7H94_22375)	62499..62639	-	141	Protein_76	type II toxin-antitoxin system YhaV family toxin	-
K7H94_RS22385 (K7H94_22385)	64840..65874	+	1035	WP_222952518.1	tyrosine-type recombinase/integrase	-
K7H94_RS22390 (K7H94_22390)	65883..66458	-	576	WP_222952519.1	PIN domain-containing protein	-
K7H94_RS22395 (K7H94_22395)	66455..66913	-	459	WP_222952520.1	helix-turn-helix domain-containing protein	-
K7H94_RS22400 (K7H94_22400)	67374..67661	-	288	WP_222952521.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
K7H94_RS22405 (K7H94_22405)	67658..67909	-	252	WP_222952522.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
K7H94_RS22410 (K7H94_22410)	68705..69634	+	930	WP_222952523.1	type VI secretion system ImpA family N-terminal domain-containing protein	-
K7H94_RS22415 (K7H94_22415)	69657..70196	+	540	WP_222952524.1	type VI secretion system contractile sheath small subunit	-
K7H94_RS22420 (K7H94_22420)	70199..71719	+	1521	WP_222952525.1	type VI secretion system contractile sheath large subunit	-
K7H94_RS22425 (K7H94_22425)	71793..72311	+	519	WP_222952526.1	type VI secretion system tube protein Hcp	-
K7H94_RS22430 (K7H94_22430)	72373..72807	+	435	WP_222952527.1	GPW/gp25 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..181041	181041

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11160.13 Da
• Isoelectric Point: 10.3519

>T214635 WP_222952521.1 NZ_CP082348:c67661-67374 [Pantoea dispersa]
VTYAVKFREDALKEWHKLDKAIQQQFARKLKKCCENPHIFSAKLRGIKDCYKIKLRASGFRLVYQVTDDELIIAVVAVGK
RERSDVYKLASERMR

Nucleotide

• Length: 288 bp

>T214635 NZ_CP110154:c133283-132801 [Klebsiella pneumoniae]
ATGGGAATGAGAGCGCCTGAATCCCTGACGGCTGAACATAACATCGCTGAGTTCTGCTGCCAGGAGCCTGCCCTTAATGA
GTGGTTAAAGAAGAAGGCTCTCAGAAACCACAGTACCGGCATTTCCCGTGTCTATGTCGTCTGCGCAGAAAACACTAACC
GGGTCATCGGTTATTATTGTTTATCTTCGGGTAGCGTCCACCGTAACACAGTGCCTGGGGCCTATAGACGCAACGCGCCT
GATGTCATTCCAGTCATTGTTTTGGGACGGCTTGCCATCGACCAGGCCTGGGCCGGGAATGGGCTTGGTGCCGCACTTCT
TAAGGATGCTATATACCGTACGCAAAACATAGCCTTTCAGGTCGGGGTGAGAGCACTGGCCGTGCATGCGCTGAATGAAG
AAGTTAAATGTTTTTACACCCGTTTTGGCTTTGAGCCTTCCATAGTCAACACGCTGACATTGTTATTCCCGATAAAAGTC
TGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9153.43 Da
• Isoelectric Point: 4.2965

>AT214635 WP_222952522.1 NZ_CP082348:c67909-67658 [Pantoea dispersa]
MPHIILSDTSASVSELKKNPMATVSAGDGFPVAILNRNQPAFYCVPAELYEQMLDAIDDQELVRLVRGRGQQPLHDVDLD
AFL

Nucleotide

• Length: 252 bp

>AT214635 NZ_CP110154:c133552-133274 [Klebsiella pneumoniae]
ATGAAACCAGACGTTCGTGAAGCTCCGATTAATATCCGGGCCAAAACATCCCAGCGTGACCTGATCGACATGGCCGCAAG
CCTGGTCTCAAAATCACGGACTGATTTTATGCTTGAGGTTGCCTGCAGGGAGGCACAGGACATTCTGCTTGATCAACGCC
TGTTCCTCCTCAATGACAATCAGTTTGAGGCGTTTATTGAAGAGCTTGACGCCCCAATAACGCCGGAGCGCCAGGCGCGA
ATCGATAACCTGATGAACCGCAAATCACCATGGGAATGA