Detailed information of TA system TA214628

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): stbDE/ParE-DnaT
• Location: 78693..79227
• Replicon: plasmid unnamed
• Accession: NZ_CP082347
• Organism: Pantoea dispersa strain Lsch

Toxin (Protein)

• Gene name: stbE
• Uniprot ID: -
• Locus tag: K7H94_RS19120
• Protein ID: WP_058758676.1
• Coordinates: 78693..78983 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: stbD
• Uniprot ID: A0A246NFI2
• Locus tag: K7H94_RS19125
• Protein ID: WP_058758675.1
• Coordinates: 78973..79227 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K7H94_RS19090 (K7H94_19090)	74302..74535	-	234	WP_058781352.1	hypothetical protein	-
K7H94_RS19095 (K7H94_19095)	74593..75273	-	681	WP_222952378.1	O-methyltransferase	-
K7H94_RS19100 (K7H94_19100)	75367..76005	+	639	WP_058770564.1	TetR family transcriptional regulator	-
K7H94_RS19105 (K7H94_19105)	76141..76962	+	822	WP_021508741.1	Cof-type HAD-IIB family hydrolase	-
K7H94_RS19110 (K7H94_19110)	77049..77477	-	429	WP_222952269.1	helix-turn-helix domain-containing protein	-
K7H94_RS19115 (K7H94_19115)	77586..78635	+	1050	WP_222952270.1	NAD(P)-dependent alcohol dehydrogenase	-
K7H94_RS19120 (K7H94_19120)	78693..78983	-	291	WP_058758676.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
K7H94_RS19125 (K7H94_19125)	78973..79227	-	255	WP_058758675.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
K7H94_RS19130 (K7H94_19130)	79452..81287	+	1836	WP_222952271.1	methyl-accepting chemotaxis protein	-
K7H94_RS19135 (K7H94_19135)	81462..82538	+	1077	WP_021508737.1	diguanylate cyclase	-
K7H94_RS19140 (K7H94_19140)	82539..83000	-	462	WP_222952272.1	OsmC family protein	-
K7H94_RS19145 (K7H94_19145)	83130..83900	-	771	WP_222952273.1	GntR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	iroN	1..689940	689940

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-82)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11277.15 Da
• Isoelectric Point: 10.4586

>T214628 WP_058758676.1 NZ_CP082347:c78983-78693 [Pantoea dispersa]
MTYKLKFVPSAEKEWKKLGHPVREQFKKKLVQRLENPRVPSAQLHGRKDQYKIKLRASGYRLVYLVQDETITVMVLGVGK
REGSQVYADTEYRLPE

Nucleotide

• Length: 291 bp

>T214628 NZ_CP110153:c4800242-4799709 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9288.50 Da
• Isoelectric Point: 3.9370

>AT214628 WP_058758675.1 NZ_CP082347:c79227-78973 [Pantoea dispersa]
MPFQILSNTAASITDLKRDPMGTVRSAEGETIAILNRNEPAFYCVPPAVYQYLMELAEDAELGRIADERISELADAKEIS
LDDL

Nucleotide

• Length: 255 bp

>AT214628 NZ_CP110153:c4800519-4800253 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A246NFI2