Detailed information of TA system TA214626

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 3589049..3589953
• Replicon: chromosome
• Accession: NZ_CP082346
• Organism: Pantoea dispersa strain Lsch

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: K7H94_RS16795
• Protein ID: WP_088515717.1
• Coordinates: 3589489..3589953 (+)
• Length: 155 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A246NMT1
• Locus tag: K7H94_RS16790
• Protein ID: WP_058757556.1
• Coordinates: 3589049..3589492 (+)
• Length: 148 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K7H94_RS16770 (K7H94_16770)	3585160..3585555	+	396	WP_031279757.1	transposase	-
K7H94_RS16775 (K7H94_16775)	3586465..3587418	-	954	WP_058757553.1	DMT family transporter	-
K7H94_RS16780 (K7H94_16780)	3587491..3588321	-	831	WP_058757554.1	AraC family transcriptional regulator	-
K7H94_RS16785 (K7H94_16785)	3588448..3588975	+	528	WP_222951377.1	isochorismatase family protein	-
K7H94_RS16790 (K7H94_16790)	3589049..3589492	+	444	WP_058757556.1	DUF2384 domain-containing protein	Antitoxin
K7H94_RS16795 (K7H94_16795)	3589489..3589953	+	465	WP_088515717.1	RES domain-containing protein	Toxin
K7H94_RS16800 (K7H94_16800)	3590005..3590547	-	543	WP_021507842.1	single-stranded DNA-binding protein SSB1	-
K7H94_RS16805 (K7H94_16805)	3590769..3593597	+	2829	WP_021507843.1	excinuclease ABC subunit UvrA	-
K7H94_RS16810 (K7H94_16810)	3593873..3594937	+	1065	WP_058757558.1	NAD(P)-dependent alcohol dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-147)

Antitoxin

• Antitoxin Xre (15-147)

Sequences

Toxin

Protein

• Length: 155 a.a.
• Molecular weight: 17083.58 Da
• Isoelectric Point: 5.1259

>T214626 WP_088515717.1 NZ_CP082346:3589489-3589953 [Pantoea dispersa]
VIFYRLTKSQYAAEAWSGYGAKQYGGRWNHKGYPTVYVATSVSLAALEVLVHIGRESVLDEYTLLSIDIPDAEVAYLAEA
FLPPDWRHDPAPLSTMDLGTGWLQSAEGAALMLPSTIIPMENNAILNPLHPAFSDYLPGVKALPFMFDRRLIRT

Nucleotide

• Length: 465 bp

>T214626 NZ_CP110153:c4024110-4023793 [Klebsiella pneumoniae]
ATGTTCAGATTGGTTGTGCATGTGGACGTTAAAAAGGAATTGCAGGCGCTTCCGCCCATTGTCCAGGCGAAGATGATCCG
GCAATTAGACAAGTTACGCCAAAATCCCACCGCGCTGAGAGAACCTGACAGTAAACCGCTGGGGCAGGGGCTATTTGAAA
TTCGTGCGTTAGGTTCGGTACAGGGGCGAGGGATCTACGTTTTTCAGCAAGGCAAGACGCTCTTTCTGCTACGGGTTTTT
GTCAAGAAAACGCAAAAAACCCCGTCATCGGAAATTCGCCTGGCGCTGAAGCGATTAGAGGAGATGCGCAATGAGTAA

Antitoxin

Protein

• Length: 148 a.a.
• Molecular weight: 16114.59 Da
• Isoelectric Point: 9.9132

>AT214626 WP_058757556.1 NZ_CP082346:3589049-3589492 [Pantoea dispersa]
MRAYIPQPGANDNALWRVAGLPPRGIELTRMLEAGLPVAVIDDIRHWSAMTRAEIMKVTGINERNIARRKSTGKSLSPDE
SERVARFVRVMDAAVQLFAGNKEEATQWLSRPVKGLGNVAPITLLTTESGALDVLDLIGRLEHGVFS

Nucleotide

• Length: 444 bp

>AT214626 NZ_CP110153:c4023800-4023513 [Klebsiella pneumoniae]
ATGAGTAAAAAGATCATTGACTGGGATACGTTAAAAACAGAACTGCTTGGCCAGCCTGAGGTTCAGGCTGCATTCGATGC
GCAAGAACGTCAACAGCGATTACGTACTATGCTGGCGCAATGGCGCGAGCAGGCGGGGCTAACCCGAGCCCAGGTGGCGC
AGAGGATGGGGGTGAGTGCGCCGACAGTCTCCAGAATGGAAGCCAATATCACCCGCGCCAGTCTGGATACCTTAACGCGA
TACGCGTTAGCCTGCGGTATAAAGCACCCGCAAGTTTTACTTTACTAA

Structures

Antitoxin

• AlphaFold DB: A0A246NMT1