Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2942474..2943094 Replicon chromosome
Accession NZ_CP082346
Organism Pantoea dispersa strain Lsch

Toxin (Protein)


Gene name Hha Uniprot ID A0A246NIG6
Locus tag K7H94_RS13845 Protein ID WP_021507203.1
Coordinates 2942876..2943094 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A246NI99
Locus tag K7H94_RS13840 Protein ID WP_021313568.1
Coordinates 2942474..2942851 (+) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K7H94_RS13810 (K7H94_13810) 2938797..2939054 + 258 WP_021507208.1 type B 50S ribosomal protein L31 -
K7H94_RS13815 (K7H94_13815) 2939070..2939210 + 141 WP_010616859.1 type B 50S ribosomal protein L36 -
K7H94_RS13820 (K7H94_13820) 2939255..2940133 - 879 WP_058769397.1 metal ABC transporter substrate-binding protein -
K7H94_RS13825 (K7H94_13825) 2940155..2940994 - 840 WP_021507206.1 metal ABC transporter permease -
K7H94_RS13830 (K7H94_13830) 2940991..2941647 - 657 WP_141496706.1 ABC transporter ATP-binding protein -
K7H94_RS13835 (K7H94_13835) 2941975..2942328 + 354 WP_031279656.1 hypothetical protein -
K7H94_RS13840 (K7H94_13840) 2942474..2942851 + 378 WP_021313568.1 Hha toxicity modulator TomB Antitoxin
K7H94_RS13845 (K7H94_13845) 2942876..2943094 + 219 WP_021507203.1 HHA domain-containing protein Toxin
K7H94_RS13855 (K7H94_13855) 2943496..2943807 + 312 WP_021507202.1 MGMT family protein -
K7H94_RS13860 (K7H94_13860) 2943974..2944531 - 558 WP_222951201.1 YbaY family lipoprotein -
K7H94_RS13865 (K7H94_13865) 2944547..2944738 + 192 WP_222951202.1 hypothetical protein -
K7H94_RS13870 (K7H94_13870) 2944735..2945598 + 864 WP_058757950.1 acyl-CoA thioesterase II -
K7H94_RS13875 (K7H94_13875) 2945671..2946960 - 1290 WP_058757951.1 ammonium transporter AmtB -
K7H94_RS13880 (K7H94_13880) 2946994..2947332 - 339 WP_007886947.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8538.87 Da        Isoelectric Point: 8.8662

>T214624 WP_021507203.1 NZ_CP082346:2942876-2943094 [Pantoea dispersa]
MSNPALTKTDYLMRLRRCRSIDTLERVIEKNKYELPDDELAVFYSAADHRLAELTMNKLYDKVPGSVWKYVR

Download         Length: 219 bp

>T214624 NZ_CP110153:1916895-1916997 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 14665.34 Da        Isoelectric Point: 4.4796

>AT214624 WP_021313568.1 NZ_CP082346:2942474-2942851 [Pantoea dispersa]
MDEYSPKRHDIAQLKFLCENLFDESMATLTDSHHGWVNDPTSPGNLQLNDLIEHIASFTMNYKIKHVEDEALITQIDEYL
DDTFMLFSSYGINTQDLQRWQRSAKRLFNLFAEECAYLQQPSHSF

Download         Length: 378 bp

>AT214624 NZ_CP110153:c1917004-1916859 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A246NIG6

Antitoxin

Source ID Structure
AlphaFold DB A0A246NI99

References