Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2378456..2379070 Replicon chromosome
Accession NZ_CP082346
Organism Pantoea dispersa strain Lsch

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag K7H94_RS11060 Protein ID WP_059010332.1
Coordinates 2378456..2378638 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag K7H94_RS11065 Protein ID WP_022548759.1
Coordinates 2378678..2379070 (+) Length 131 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K7H94_RS11005 (K7H94_11005) 2373601..2374263 + 663 WP_222951039.1 MBL fold metallo-hydrolase -
K7H94_RS11010 (K7H94_11010) 2374264..2374677 - 414 WP_058757613.1 GNAT family N-acetyltransferase -
K7H94_RS11015 (K7H94_11015) 2374699..2375082 - 384 WP_058757612.1 hypothetical protein -
K7H94_RS11020 (K7H94_11020) 2375300..2375656 + 357 WP_010617204.1 DUF4186 domain-containing protein -
K7H94_RS11025 (K7H94_11025) 2375675..2375854 - 180 WP_031279245.1 hypothetical protein -
K7H94_RS11030 (K7H94_11030) 2376058..2376387 + 330 WP_222951040.1 hypothetical protein -
K7H94_RS11035 (K7H94_11035) 2376449..2376997 + 549 WP_058769856.1 hypothetical protein -
K7H94_RS11040 (K7H94_11040) 2377022..2377228 - 207 WP_021506367.1 DUF2767 family protein -
K7H94_RS11045 (K7H94_11045) 2377409..2377657 + 249 WP_021506368.1 DUF883 family protein -
K7H94_RS11050 (K7H94_11050) 2377692..2377889 - 198 WP_153002028.1 hypothetical protein -
K7H94_RS11055 (K7H94_11055) 2377990..2378187 - 198 WP_021506369.1 DUF6404 family protein -
K7H94_RS11060 (K7H94_11060) 2378456..2378638 + 183 WP_059010332.1 type II toxin-antitoxin system HicA family toxin Toxin
K7H94_RS11065 (K7H94_11065) 2378678..2379070 + 393 WP_022548759.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
K7H94_RS11070 (K7H94_11070) 2379155..2380411 + 1257 WP_222951041.1 mechanosensitive ion channel -
K7H94_RS11075 (K7H94_11075) 2380534..2381784 - 1251 WP_010617214.1 NADP-dependent isocitrate dehydrogenase -
K7H94_RS11080 (K7H94_11080) 2381886..2382554 + 669 WP_150058306.1 23S rRNA pseudouridine(2457) synthase RluE -
K7H94_RS11085 (K7H94_11085) 2382599..2383072 + 474 WP_215786129.1 NUDIX hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-58)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-124)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6924.17 Da        Isoelectric Point: 10.9062

>T214623 WP_059010332.1 NZ_CP082346:2378456-2378638 [Pantoea dispersa]
MKSATLIKLLQKNGWKLERIRGSHHQFSHPDLAHLITVPHPQKDMKTGTLMQILKDARLD

Download         Length: 183 bp

>T214623 NZ_CP110153:851817-852227 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGACGGATCCATGCCCGTCGCGGGGAAATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 131 a.a.        Molecular weight: 14554.49 Da        Isoelectric Point: 4.8732

>AT214623 WP_022548759.1 NZ_CP082346:2378678-2379070 [Pantoea dispersa]
MLFPALVEIDADGSASGYFPDVTGCYFAGDTPEQTLQDAQSALHAHFELMAEKGLLIPEPAQHWQQEFSQPGVWIYVDID
VTRYLGKSERINITMPHLLIEKIDKMVSNNARYSSRSHFLAEAARKALVS

Download         Length: 393 bp

>AT214623 NZ_CP110153:851570-851836 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References