Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 586465..587060 Replicon plasmid unnamed
Accession NZ_CP082342
Organism Pantoea dispersa strain AHKW2b

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag K7X52_RS22570 Protein ID WP_088517421.1
Coordinates 586465..586842 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag K7X52_RS22575 Protein ID WP_088517422.1
Coordinates 586839..587060 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K7X52_RS22545 (K7X52_22545) 581539..581886 - 348 WP_021508880.1 helix-turn-helix transcriptional regulator -
K7X52_RS22550 (K7X52_22550) 582046..583272 + 1227 WP_222986886.1 MFS transporter -
K7X52_RS22555 (K7X52_22555) 583482..583760 + 279 WP_222986888.1 helix-turn-helix transcriptional regulator -
K7X52_RS22560 (K7X52_22560) 583834..585198 - 1365 WP_247653161.1 H(+)/Cl(-) exchange transporter ClcA -
K7X52_RS22565 (K7X52_22565) 585535..586458 + 924 WP_166719384.1 glutaminase B -
K7X52_RS22570 (K7X52_22570) 586465..586842 - 378 WP_088517421.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
K7X52_RS22575 (K7X52_22575) 586839..587060 - 222 WP_088517422.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
K7X52_RS22580 (K7X52_22580) 587352..587768 + 417 WP_222986889.1 DUF2946 domain-containing protein -
K7X52_RS22585 (K7X52_22585) 587834..589573 + 1740 WP_222986891.1 DUF2534 family protein -
K7X52_RS22590 (K7X52_22590) 589654..590670 - 1017 WP_021508873.1 NAD(P)-dependent alcohol dehydrogenase -
K7X52_RS22595 (K7X52_22595) 590794..591063 - 270 WP_010616678.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - iroN 1..653898 653898


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-51)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13976.94 Da        Isoelectric Point: 7.4656

>T214620 WP_088517421.1 NZ_CP082342:c586842-586465 [Pantoea dispersa]
MNHVSADEVIALHDYVLRRYAGVTGMQDPGRAQAIVTRVINRQFYEGVQDVYELAATYWVAISRGHIFADANKRTSLNVT
MLFLKRNGVKVHDRPELVELTVMAATGEAGIDDLARALRSFFSAH

Download         Length: 378 bp

>T214620 NZ_CP110151:c81277-80852 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGTGGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAAGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCT
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACCGCCATTGC
CGGACACGCCATCGCGGCGGGCGCCATCCTGGTGACGAATAATACAAGAGAGTTTGAGCGGGTGCCGGGTCTGGTTCTGG
AAGACTGGGTTGGCTTTGTTGAATAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 7999.82 Da        Isoelectric Point: 4.5026

>AT214620 WP_088517422.1 NZ_CP082342:c587060-586839 [Pantoea dispersa]
MNKFTYTSARENFSQVLDQAIAGEAVEITRRSGDSAVVISKAHFDAYRKAALDAEFAELIGEFDASNQALADR

Download         Length: 222 bp

>AT214620 NZ_CP110151:c81504-81274 [Klebsiella pneumoniae]
ATGCGCACAGTATCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGATCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGACGAAGGACGCTTTGATCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References