Detailed information of TA system TA214617

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 263538..264073
• Replicon: plasmid unnamed
• Accession: NZ_CP082342
• Organism: Pantoea dispersa strain AHKW2b

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A246NE43
• Locus tag: K7X52_RS21095
• Protein ID: WP_058770149.1
• Coordinates: 263538..263825 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: K7X52_RS21100
• Protein ID: WP_088517619.1
• Coordinates: 263822..264073 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K7X52_RS21075 (K7X52_21075)	259284..260255	+	972	WP_058758760.1	autoinducer 2 ABC transporter substrate-binding protein	-
K7X52_RS21080 (K7X52_21080)	260267..261208	+	942	WP_222987117.1	ABC transporter permease	-
K7X52_RS21085 (K7X52_21085)	261205..262149	+	945	WP_222987118.1	ABC transporter permease	-
K7X52_RS21090 (K7X52_21090)	262153..263487	+	1335	WP_222987119.1	ArgE/DapE family deacylase	-
K7X52_RS21095 (K7X52_21095)	263538..263825	-	288	WP_058770149.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
K7X52_RS21100 (K7X52_21100)	263822..264073	-	252	WP_088517619.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
K7X52_RS21105 (K7X52_21105)	264205..266394	-	2190	WP_222987120.1	aldehyde oxidoreductase molybdenum-binding subunit PaoC	-
K7X52_RS21110 (K7X52_21110)	266391..267347	-	957	WP_222987121.1	xanthine dehydrogenase family protein subunit M	-
K7X52_RS21115 (K7X52_21115)	267344..267964	-	621	WP_104093614.1	aldehyde dehydrogenase iron-sulfur subunit PaoA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	iroN	1..653898	653898

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11155.16 Da
• Isoelectric Point: 10.4346

>T214617 WP_058770149.1 NZ_CP082342:c263825-263538 [Pantoea dispersa]
VTWTVKFREEALKEWHKLDKAIQQQFAKKLKKCCENPHIPSAKLRGIKDCYKIKLRASGFRLVYQVIDDQLIIAVVAVGK
RERSDVYHLASDRMR

Nucleotide

• Length: 288 bp

>T214617 NZ_CP110150:c5123370-5122987 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTACCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9256.65 Da
• Isoelectric Point: 4.1789

>AT214617 WP_088517619.1 NZ_CP082342:c264073-263822 [Pantoea dispersa]
MPNIILSDMSASVSELKKNPMATVNAGEGLPVAILNRNQPAFYCVPAQLYEQMLEALDDQELVKKVTERHQQPLIDVDLD
SFL

Nucleotide

• Length: 252 bp

>AT214617 NZ_CP110150:c5123612-5123370 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Structures

Toxin

• AlphaFold DB: A0A246NE43