Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3780611..3781310 Replicon chromosome
Accession NZ_CP082341
Organism Pantoea dispersa strain AHKW2b

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag K7X52_RS17835 Protein ID WP_072208527.1
Coordinates 3781134..3781310 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag K7X52_RS17830 Protein ID WP_222985890.1
Coordinates 3780611..3781015 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K7X52_RS17820 (K7X52_17820) 3778114..3779553 - 1440 WP_222986717.1 PTS N-acetylmuramic acid transporter subunit IIBC -
K7X52_RS17825 (K7X52_17825) 3779553..3780464 - 912 WP_058757601.1 N-acetylmuramic acid 6-phosphate etherase -
K7X52_RS17830 (K7X52_17830) 3780611..3781015 - 405 WP_222985890.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
K7X52_RS17835 (K7X52_17835) 3781134..3781310 - 177 WP_072208527.1 type II toxin-antitoxin system HicA family toxin Toxin
K7X52_RS17840 (K7X52_17840) 3781485..3782786 - 1302 WP_058757544.1 glutamate/aspartate:proton symporter GltP -
K7X52_RS17845 (K7X52_17845) 3783367..3785322 + 1956 WP_058774926.1 acetate--CoA ligase -
K7X52_RS17850 (K7X52_17850) 3785496..3785825 + 330 WP_021313201.1 DUF485 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-55)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6824.11 Da        Isoelectric Point: 10.6691

>T214613 WP_072208527.1 NZ_CP082341:c3781310-3781134 [Pantoea dispersa]
MSSRELIRMLLERGWILDRVKGSHHVFVRADKPYHISLPHPEKDLATGTLRKLLKMMD

Download         Length: 177 bp

>T214613 NZ_CP110150:c4509520-4508987 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATAAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14641.36 Da        Isoelectric Point: 4.9322

>AT214613 WP_222985890.1 NZ_CP082341:c3781015-3780611 [Pantoea dispersa]
MRFPVYLHKTENGSWSGFVPDVQGCFFAGNSVDEALSDAFGAIDAHVESLADAGKAIPKAASVETHINDEECQGGYWAFV
EIDLSRYEGKAVKLNITLPQNLLTKIDSHVEAHREYGSRSGFLAALARRELANI

Download         Length: 405 bp

>AT214613 NZ_CP110150:c4509797-4509531 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References