Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3487427..3488184 Replicon chromosome
Accession NZ_CP082341
Organism Pantoea dispersa strain AHKW2b

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag K7X52_RS16425 Protein ID WP_088515934.1
Coordinates 3487702..3488184 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag K7X52_RS16420 Protein ID WP_088515933.1
Coordinates 3487427..3487711 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K7X52_RS16400 (K7X52_16400) 3482791..3483510 + 720 WP_222985783.1 TIGR03761 family integrating conjugative element protein -
K7X52_RS16405 (K7X52_16405) 3483528..3485540 + 2013 WP_222985784.1 DNA topoisomerase III -
K7X52_RS16410 (K7X52_16410) 3486171..3486662 + 492 WP_222985785.1 STY4534 family ICE replication protein -
K7X52_RS16415 (K7X52_16415) 3486735..3487283 + 549 WP_088515932.1 single-stranded DNA-binding protein -
K7X52_RS16420 (K7X52_16420) 3487427..3487711 + 285 WP_088515933.1 DUF1778 domain-containing protein Antitoxin
K7X52_RS16425 (K7X52_16425) 3487702..3488184 + 483 WP_088515934.1 GNAT family N-acetyltransferase Toxin
K7X52_RS16430 (K7X52_16430) 3488534..3488845 + 312 WP_141097284.1 hypothetical protein -
K7X52_RS16435 (K7X52_16435) 3489027..3489458 + 432 WP_222985786.1 DUF29 domain-containing protein -
K7X52_RS16440 (K7X52_16440) 3489729..3491027 + 1299 WP_222985787.1 TcpQ domain-containing protein -
K7X52_RS16445 (K7X52_16445) 3491029..3491472 + 444 WP_222985788.1 type IV pilus biogenesis protein PilM -
K7X52_RS16450 (K7X52_16450) 3491492..3493165 + 1674 WP_222985789.1 PilN family type IVB pilus formation outer membrane protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 3474881..3575043 100162


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(34-149)

Antitoxin

Vibrio phage ICP1, Orf50

(13-87)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17776.50 Da        Isoelectric Point: 7.3557

>T214611 WP_088515934.1 NZ_CP082341:3487702-3488184 [Pantoea dispersa]
MEIKVTAPALLTEGHDLEPFDSGNIVLDDWLRRRALKNQHLNASRTFVICLEGTMRVVGYYSIATGSVSHVDLSRSLRQN
MPDPVPVVLLGRLAVDVTTQGNKFGKWLLNDAVIRVSNLADQVGIKAIMVHAIDEQAKAFYDYFGFVQSPVAANTLFYKI

Download         Length: 483 bp

>T214611 NZ_CP110150:c2588336-2587014 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCACTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCAGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
AAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCGCCACTCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCGGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 11260.77 Da        Isoelectric Point: 5.8990

>AT214611 WP_088515933.1 NZ_CP082341:3487427-3487711 [Pantoea dispersa]
MQTTFRKSVRDKQINIRATDEERAVIDYAASLVNKNRTDFIIERAVHEAQNIILDQRVFILDDERYQEFIRQLEAPVQNV
EGRQRLMDVKPEWK

Download         Length: 285 bp

>AT214611 NZ_CP110150:c2588602-2588336 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGACGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References