Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3053132..3053752 Replicon chromosome
Accession NZ_CP082341
Organism Pantoea dispersa strain AHKW2b

Toxin (Protein)


Gene name Hha Uniprot ID A0A246NIG6
Locus tag K7X52_RS14405 Protein ID WP_021507203.1
Coordinates 3053534..3053752 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A246NI99
Locus tag K7X52_RS14400 Protein ID WP_021313568.1
Coordinates 3053132..3053509 (+) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K7X52_RS14370 (K7X52_14370) 3049455..3049712 + 258 WP_021507208.1 type B 50S ribosomal protein L31 -
K7X52_RS14375 (K7X52_14375) 3049728..3049868 + 141 WP_010616859.1 type B 50S ribosomal protein L36 -
K7X52_RS14380 (K7X52_14380) 3049913..3050791 - 879 WP_222985648.1 metal ABC transporter substrate-binding protein -
K7X52_RS14385 (K7X52_14385) 3050813..3051652 - 840 WP_021507206.1 metal ABC transporter permease -
K7X52_RS14390 (K7X52_14390) 3051649..3052305 - 657 WP_222985650.1 ABC transporter ATP-binding protein -
K7X52_RS14395 (K7X52_14395) 3052633..3052986 + 354 WP_088516249.1 hypothetical protein -
K7X52_RS14400 (K7X52_14400) 3053132..3053509 + 378 WP_021313568.1 Hha toxicity modulator TomB Antitoxin
K7X52_RS14405 (K7X52_14405) 3053534..3053752 + 219 WP_021507203.1 HHA domain-containing protein Toxin
K7X52_RS14415 (K7X52_14415) 3054154..3054465 + 312 WP_021507202.1 MGMT family protein -
K7X52_RS14420 (K7X52_14420) 3054633..3055190 - 558 WP_021507201.1 YbaY family lipoprotein -
K7X52_RS14425 (K7X52_14425) 3055206..3055397 + 192 WP_222985652.1 hypothetical protein -
K7X52_RS14430 (K7X52_14430) 3055394..3056257 + 864 WP_088516247.1 acyl-CoA thioesterase II -
K7X52_RS14435 (K7X52_14435) 3056330..3057619 - 1290 WP_058757951.1 ammonium transporter AmtB -
K7X52_RS14440 (K7X52_14440) 3057653..3057991 - 339 WP_007886947.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8538.87 Da        Isoelectric Point: 8.8662

>T214610 WP_021507203.1 NZ_CP082341:3053534-3053752 [Pantoea dispersa]
MSNPALTKTDYLMRLRRCRSIDTLERVIEKNKYELPDDELAVFYSAADHRLAELTMNKLYDKVPGSVWKYVR

Download         Length: 219 bp

>T214610 NZ_CP110150:1866753-1866855 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 14665.34 Da        Isoelectric Point: 4.4796

>AT214610 WP_021313568.1 NZ_CP082341:3053132-3053509 [Pantoea dispersa]
MDEYSPKRHDIAQLKFLCENLFDESMATLTDSHHGWVNDPTSPGNLQLNDLIEHIASFTMNYKIKHVEDEALITQIDEYL
DDTFMLFSSYGINTQDLQRWQRSAKRLFNLFAEECAYLQQPSHSF

Download         Length: 378 bp

>AT214610 NZ_CP110150:c1866862-1866717 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A246NIG6

Antitoxin

Source ID Structure
AlphaFold DB A0A246NI99

References