Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-HicB |
| Location | 2504487..2505101 | Replicon | chromosome |
| Accession | NZ_CP082341 | ||
| Organism | Pantoea dispersa strain AHKW2b | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | A0A246NCD7 |
| Locus tag | K7X52_RS11680 | Protein ID | WP_058757609.1 |
| Coordinates | 2504487..2504669 (+) | Length | 61 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | - |
| Locus tag | K7X52_RS11685 | Protein ID | WP_022548759.1 |
| Coordinates | 2504709..2505101 (+) | Length | 131 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K7X52_RS11630 (K7X52_11630) | 2499632..2500294 | + | 663 | WP_021506360.1 | MBL fold metallo-hydrolase | - |
| K7X52_RS11635 (K7X52_11635) | 2500295..2500708 | - | 414 | WP_058757613.1 | GNAT family N-acetyltransferase | - |
| K7X52_RS11640 (K7X52_11640) | 2500730..2501113 | - | 384 | WP_058757612.1 | hypothetical protein | - |
| K7X52_RS11645 (K7X52_11645) | 2501331..2501687 | + | 357 | WP_010617204.1 | DUF4186 domain-containing protein | - |
| K7X52_RS11650 (K7X52_11650) | 2501706..2501885 | - | 180 | WP_031279245.1 | hypothetical protein | - |
| K7X52_RS11655 (K7X52_11655) | 2502089..2502418 | + | 330 | WP_166718692.1 | hypothetical protein | - |
| K7X52_RS11660 (K7X52_11660) | 2502480..2503028 | + | 549 | WP_058769856.1 | hypothetical protein | - |
| K7X52_RS11665 (K7X52_11665) | 2503053..2503259 | - | 207 | WP_058769647.1 | DUF2767 family protein | - |
| K7X52_RS11670 (K7X52_11670) | 2503440..2503688 | + | 249 | WP_021506368.1 | DUF883 family protein | - |
| K7X52_RS11675 (K7X52_11675) | 2504021..2504218 | - | 198 | WP_021506369.1 | DUF6404 family protein | - |
| K7X52_RS11680 (K7X52_11680) | 2504487..2504669 | + | 183 | WP_058757609.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| K7X52_RS11685 (K7X52_11685) | 2504709..2505101 | + | 393 | WP_022548759.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| K7X52_RS11690 (K7X52_11690) | 2505186..2506442 | + | 1257 | WP_222985397.1 | mechanosensitive ion channel | - |
| K7X52_RS11695 (K7X52_11695) | 2506565..2507815 | - | 1251 | WP_222985398.1 | NADP-dependent isocitrate dehydrogenase | - |
| K7X52_RS11700 (K7X52_11700) | 2507917..2508594 | + | 678 | WP_222985399.1 | 23S rRNA pseudouridine(2457) synthase RluE | - |
| K7X52_RS11705 (K7X52_11705) | 2508639..2509112 | + | 474 | WP_031279253.1 | NUDIX hydrolase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 61 a.a. Molecular weight: 6958.19 Da Isoelectric Point: 10.9062
>T214609 WP_058757609.1 NZ_CP082341:2504487-2504669 [Pantoea dispersa]
MKSATLIKLLQKNGWKLERIRGSHHQFSHPDFAHLITVPHPQKDMKTGTLMQILKDARLD
MKSATLIKLLQKNGWKLERIRGSHHQFSHPDFAHLITVPHPQKDMKTGTLMQILKDARLD
Download Length: 183 bp
>T214609 NZ_CP110150:857835-858245 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA
Antitoxin
Download Length: 131 a.a. Molecular weight: 14554.49 Da Isoelectric Point: 4.8732
>AT214609 WP_022548759.1 NZ_CP082341:2504709-2505101 [Pantoea dispersa]
MLFPALVEIDADGSASGYFPDVTGCYFAGDTPEQTLQDAQSALHAHFELMAEKGLLIPEPAQHWQQEFSQPGVWIYVDID
VTRYLGKSERINITMPHLLIEKIDKMVSNNARYSSRSHFLAEAARKALVS
MLFPALVEIDADGSASGYFPDVTGCYFAGDTPEQTLQDAQSALHAHFELMAEKGLLIPEPAQHWQQEFSQPGVWIYVDID
VTRYLGKSERINITMPHLLIEKIDKMVSNNARYSSRSHFLAEAARKALVS
Download Length: 393 bp
>AT214609 NZ_CP110150:857588-857854 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|