Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1605822..1606439 Replicon chromosome
Accession NZ_CP082341
Organism Pantoea dispersa strain AHKW2b

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag K7X52_RS07335 Protein ID WP_222986461.1
Coordinates 1605822..1606010 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag K7X52_RS07340 Protein ID WP_058781997.1
Coordinates 1606029..1606439 (+) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K7X52_RS07320 (K7X52_07320) 1602712..1603497 - 786 WP_262417921.1 PhnD/SsuA/transferrin family substrate-binding protein -
K7X52_RS07325 (K7X52_07325) 1603394..1604461 - 1068 WP_222986678.1 fatty acid desaturase -
K7X52_RS07330 (K7X52_07330) 1604679..1605701 + 1023 WP_222986460.1 LLM class flavin-dependent oxidoreductase -
K7X52_RS07335 (K7X52_07335) 1605822..1606010 + 189 WP_222986461.1 type II toxin-antitoxin system HicA family toxin Toxin
K7X52_RS07340 (K7X52_07340) 1606029..1606439 + 411 WP_058781997.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
K7X52_RS07345 (K7X52_07345) 1606628..1607455 - 828 WP_222986462.1 glycosyltransferase family 8 protein -
K7X52_RS07350 (K7X52_07350) 1607478..1608860 - 1383 WP_222986463.1 D-arabinono-1,4-lactone oxidase -
K7X52_RS07355 (K7X52_07355) 1608939..1609580 - 642 WP_125310083.1 TetR family transcriptional regulator -
K7X52_RS07360 (K7X52_07360) 1609793..1610620 + 828 WP_088518052.1 MetQ/NlpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 6960.23 Da        Isoelectric Point: 11.0007

>T214607 WP_222986461.1 NZ_CP082341:1605822-1606010 [Pantoea dispersa]
MDSRSLMAEIKADGWELIRINGSHPHFVHPTKKGLVTIPHPKKDLPIKTVKSIRKQAGLTVH

Download         Length: 189 bp

>T214607 NZ_CP110150:350625-350972 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATACCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 14780.06 Da        Isoelectric Point: 4.6268

>AT214607 WP_058781997.1 NZ_CP082341:1606029-1606439 [Pantoea dispersa]
MFYPIAIEAGDETTAYGVTVPDLPGCFSAGDTLEEAVKNAKEAITGHLELMVELGQDIPAVSDLKSLMKSAEFAGYVWVL
VDVDVTRILGGSEKINVTLPKLLIDRIDRCVATHPEFKTRSGFLAQVALERIAKTR

Download         Length: 411 bp

>AT214607 NZ_CP110150:350972-351271 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATGGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References