Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4077457..4077973 Replicon chromosome
Accession NZ_CP082338
Organism Salmonella enterica subsp. enterica strain IBG7b4

Toxin (Protein)


Gene name relE Uniprot ID A0A0R9NWE9
Locus tag K7H10_RS19800 Protein ID WP_000220579.1
Coordinates 4077457..4077741 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag K7H10_RS19805 Protein ID WP_000212724.1
Coordinates 4077731..4077973 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K7H10_RS19785 (4072669) 4072669..4074321 + 1653 WP_047605414.1 alpha,alpha-phosphotrehalase -
K7H10_RS19790 (4074730) 4074730..4076868 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
K7H10_RS19795 (4076989) 4076989..4077453 + 465 WP_001268864.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
K7H10_RS19800 (4077457) 4077457..4077741 - 285 WP_000220579.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K7H10_RS19805 (4077731) 4077731..4077973 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
K7H10_RS19810 (4078051) 4078051..4079964 - 1914 WP_045718119.1 BglG family transcription antiterminator -
K7H10_RS19815 (4079981) 4079981..4080721 - 741 WP_052934713.1 KDGP aldolase family protein -
K7H10_RS19820 (4080718) 4080718..4081836 - 1119 WP_001139182.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
K7H10_RS19825 (4081820) 4081820..4082953 - 1134 WP_000459930.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10884.70 Da        Isoelectric Point: 10.0482

>T214602 WP_000220579.1 NZ_CP082338:c4077741-4077457 [Salmonella enterica subsp. enterica]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDTNKRL

Download         Length: 285 bp

>T214602 NZ_CP110148:c5188051-5187668 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT214602 WP_000212724.1 NZ_CP082338:c4077973-4077731 [Salmonella enterica subsp. enterica]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT214602 NZ_CP110148:c5188293-5188051 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9NWE9

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References