Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3382066..3382686 Replicon chromosome
Accession NZ_CP082338
Organism Salmonella enterica subsp. enterica strain IBG7b4

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag K7H10_RS16595 Protein ID WP_001280991.1
Coordinates 3382468..3382686 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag K7H10_RS16590 Protein ID WP_000344807.1
Coordinates 3382066..3382440 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K7H10_RS16580 (3377205) 3377205..3378398 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
K7H10_RS16585 (3378421) 3378421..3381570 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
K7H10_RS16590 (3382066) 3382066..3382440 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
K7H10_RS16595 (3382468) 3382468..3382686 + 219 WP_001280991.1 HHA domain-containing protein Toxin
K7H10_RS16600 (3382865) 3382865..3383416 + 552 WP_001278792.1 maltose O-acetyltransferase -
K7H10_RS16605 (3383533) 3383533..3384003 + 471 WP_000136181.1 YlaC family protein -
K7H10_RS16610 (3384059) 3384059..3384199 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
K7H10_RS16615 (3384205) 3384205..3384465 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
K7H10_RS16620 (3384690) 3384690..3386240 + 1551 WP_052934497.1 EAL domain-containing protein -
K7H10_RS16630 (3386471) 3386471..3386860 + 390 WP_000961287.1 MGMT family protein -
K7H10_RS16635 (3386893) 3386893..3387462 - 570 WP_000779801.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T214598 WP_001280991.1 NZ_CP082338:3382468-3382686 [Salmonella enterica subsp. enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T214598 NZ_CP110148:3981190-3981408 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT214598 WP_000344807.1 NZ_CP082338:3382066-3382440 [Salmonella enterica subsp. enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT214598 NZ_CP110148:3980789-3981163 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References