21459

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4453127..4453722 Replicon chromosome
Accession NC_007779
Organism Escherichia coli str. K-12 substr. W3110

Toxin (Protein)


Gene name chpB Uniprot ID U9XNP6
Locus tag Y75_RS22050 Protein ID WP_000239577.1
Coordinates 4453372..4453722 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag Y75_RS22045 Protein ID WP_001223208.1
Coordinates 4453127..4453378 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Y75_RS22035 (Y75_p4107) 4448792..4452571 + 3780 WP_000060911.1 autotransporter assembly complex protein TamB -
Y75_RS22040 (Y75_p4108) 4452574..4452915 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
Y75_RS22045 (Y75_p4110) 4453127..4453378 + 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
Y75_RS22050 (Y75_p4111) 4453372..4453722 + 351 WP_000239577.1 endoribonuclease toxin ChpB Toxin
Y75_RS22055 (Y75_p4112) 4453802..4454332 - 531 WP_000055075.1 inorganic diphosphatase -
Y75_RS22060 (Y75_p4113) 4454642..4455598 + 957 WP_000265913.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
Y75_RS22065 (Y75_p4114) 4455738..4457240 + 1503 WP_000205805.1 sugar ABC transporter ATP-binding protein -
Y75_RS22070 (Y75_p4115) 4457254..4458276 + 1023 WP_001313531.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12492.40 Da        Isoelectric Point: 5.5572

>T21459 WP_000239577.1 NC_007779:4453372-4453722 [Escherichia coli str. K-12 substr. W3110]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLHARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T21459 NC_007779:4453372-4453722 [Escherichia coli str. K-12 substr. W3110]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACACGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT21459 WP_001223208.1 NC_007779:4453127-4453378 [Escherichia coli str. K-12 substr. W3110]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT21459 NC_007779:4453127-4453378 [Escherichia coli str. K-12 substr. W3110]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XNP6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References