Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 989359..990173 Replicon chromosome
Accession NZ_CP082338
Organism Salmonella enterica subsp. enterica strain IBG7b4

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag K7H10_RS04710 Protein ID WP_000971655.1
Coordinates 989359..989886 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag K7H10_RS04715 Protein ID WP_000855694.1
Coordinates 989883..990173 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K7H10_RS04680 (985659) 985659..986056 + 398 Protein_915 cytoplasmic protein -
K7H10_RS04685 (986247) 986247..986486 + 240 Protein_916 hypothetical protein -
K7H10_RS04690 (986643) 986643..987311 + 669 WP_000445914.1 hypothetical protein -
K7H10_RS04695 (987338) 987338..987832 + 495 WP_000424942.1 hypothetical protein -
K7H10_RS04700 (988077) 988077..988733 - 657 WP_020437799.1 protein-serine/threonine phosphatase -
K7H10_RS04705 (989071) 989071..989286 + 216 Protein_920 IS5/IS1182 family transposase -
K7H10_RS04710 (989359) 989359..989886 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
K7H10_RS04715 (989883) 989883..990173 - 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
K7H10_RS04720 (990443) 990443..990643 - 201 Protein_923 transposase -
K7H10_RS04725 (990884) 990884..991210 + 327 WP_000393302.1 hypothetical protein -
K7H10_RS04730 (991483) 991483..991830 - 348 WP_001669174.1 DUF1493 family protein -
K7H10_RS04735 (991815) 991815..992264 - 450 WP_021294302.1 hypothetical protein -
K7H10_RS04740 (992696) 992696..993139 - 444 WP_001522905.1 SPI-1 type III secretion system invasion lipoprotein InvH -
K7H10_RS04745 (993595) 993595..994245 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 989146..989286 140


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T214589 WP_000971655.1 NZ_CP082338:c989886-989359 [Salmonella enterica subsp. enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T214589 NZ_CP110146:47515-47985 [Klebsiella pneumoniae]
GTGATCTTCTACAGGCTGACGAAAACAAAGTATCTTTCTACGGCCTGGACCGGATATGGTGCGAAAGAGGCTGGTGGGCG
CTGGAATAGCGTGGGGGTGTCAATGGTATATGTCTCCGAAACGGCATCACTAACGATGCTGGAGACCCTGGTACACCTGC
ATGCGGCACAGATAATGGACTCTTTCACGCTACTGAGTATCGATGTGCCTGATGAACTGATACAAAGCGCAAACATGGAT
GAATTACCGGGCAACTGGGCTGATGAGGATGCGCCTCAGGAACTGGCTGATTACGGAGATGCCTGGTCATTTACCAGGAG
CTCGGTTGCACTGCGTGTTCCCTCAGCCTTATCGCCGGTAGAGTTCAATTATCTGTTAAATCCTGAGCACCCTGAGTTTT
ACGGGATCGTGCAGAAGGCTCAACAGATACCGTTCCGGTTTGATAGTCGTCTTAAACCTGACAGGAAGTGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT214589 WP_000855694.1 NZ_CP082338:c990173-989883 [Salmonella enterica subsp. enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT214589 NZ_CP110146:47075-47518 [Klebsiella pneumoniae]
ATGAAAACTTTTAGTTTGTCCTCAACTCCAGCCAGACCACAGCGCCTCTGGCAGGTTGCCGGGTTAAATAATGCTGATGG
TGTAGCGCTCCTGGGCCAAATCAATGAAGGCCTGGACGGGAAGGTGGTGAACCGGATCACTGACTGGGCCAGAATAACCC
AGAATGACCTGAGAAAAATGTCCGGTATCCCGTCAACCACATTTAGCCGCAGTGTGAAGGCACGTTTTAACCCGGAACAA
AGTGAACGTCTGGTACGGATTATCCGCGTTATTGATCGGGCGGTAGATTTGTTTGAAGGCGACAGGGAAGCCGCACAGAA
GTGGTTGAACGAACCTAACCGGGCATTGAGCTGGAAAGTGCCAGCAGACCTGATGGCATCCGAAACGGGAGCCTATGAGG
TCATTAAGCTGATTACGCGTCTGGAGCATGGGGTGTACTCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References