Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 824838..825498 Replicon chromosome
Accession NZ_CP082338
Organism Salmonella enterica subsp. enterica strain IBG7b4

Toxin (Protein)


Gene name cptA Uniprot ID A0A5I5GR00
Locus tag K7H10_RS03970 Protein ID WP_000244761.1
Coordinates 825085..825498 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag K7H10_RS03965 Protein ID WP_000351186.1
Coordinates 824838..825104 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K7H10_RS03945 (820766) 820766..822199 - 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -
K7H10_RS03950 (822358) 822358..822669 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
K7H10_RS03955 (822833) 822833..823492 + 660 WP_000250289.1 hemolysin III family protein -
K7H10_RS03960 (823608) 823608..824588 - 981 WP_023193393.1 tRNA-modifying protein YgfZ -
K7H10_RS03965 (824838) 824838..825104 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
K7H10_RS03970 (825085) 825085..825498 + 414 WP_000244761.1 protein YgfX Toxin
K7H10_RS03975 (825551) 825551..826072 - 522 WP_001055885.1 flavodoxin FldB -
K7H10_RS03980 (826185) 826185..827081 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
K7H10_RS03985 (827105) 827105..827818 + 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
K7H10_RS03990 (827824) 827824..829557 + 1734 WP_000813387.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16199.15 Da        Isoelectric Point: 10.7537

>T214588 WP_000244761.1 NZ_CP082338:825085-825498 [Salmonella enterica subsp. enterica]
VVLWQSDLRVSWRAQWISLLIHGLVSAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T214588 NZ_CP110145:5203313-5203660 [Klebsiella pneumoniae]
ATGTGGGATGTGGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCTTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCAATAAGGATGGCATAAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT214588 WP_000351186.1 NZ_CP082338:824838-825104 [Salmonella enterica subsp. enterica]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT214588 NZ_CP110145:5203660-5203959 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGAAAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGACTGATAACGACCCTCGGCTTTCGACCCTAAAAAGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5I5GR00

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References