Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 873615..874141 Replicon chromosome
Accession NZ_CP082336
Organism Staphylococcus arlettae strain AHKW2e

Toxin (Protein)


Gene name mazF Uniprot ID A0A7V7SNP8
Locus tag K7H07_RS04140 Protein ID WP_002509017.1
Coordinates 873785..874141 (+) Length 119 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A7V7VEP5
Locus tag K7H07_RS04135 Protein ID WP_002509016.1
Coordinates 873615..873785 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K7H07_RS04110 (K7H07_04110) 869442..869915 + 474 WP_193325507.1 PH domain-containing protein -
K7H07_RS04115 (K7H07_04115) 869908..871404 + 1497 WP_193325508.1 PH domain-containing protein -
K7H07_RS04120 (K7H07_04120) 871397..871870 + 474 WP_021459211.1 PH domain-containing protein -
K7H07_RS04125 (K7H07_04125) 871913..872266 + 354 WP_002509014.1 holo-ACP synthase -
K7H07_RS04130 (K7H07_04130) 872378..873526 + 1149 WP_002509015.1 alanine racemase -
K7H07_RS04135 (K7H07_04135) 873615..873785 + 171 WP_002509016.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
K7H07_RS04140 (K7H07_04140) 873785..874141 + 357 WP_002509017.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
K7H07_RS04145 (K7H07_04145) 874413..875414 + 1002 WP_002509018.1 PP2C family protein-serine/threonine phosphatase -
K7H07_RS04150 (K7H07_04150) 875497..875823 + 327 WP_002509019.1 anti-sigma factor antagonist -
K7H07_RS04155 (K7H07_04155) 875825..876304 + 480 WP_002509020.1 anti-sigma B factor RsbW -
K7H07_RS04160 (K7H07_04160) 876279..877049 + 771 WP_002509021.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-108)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13385.57 Da        Isoelectric Point: 10.2885

>T214587 WP_002509017.1 NZ_CP082336:873785-874141 [Staphylococcus arlettae]
MRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIRT
LDKKRLKEKLTYLSEDKMKEVNIAIDISLGLHNNRHHK

Download         Length: 357 bp

>T214587 NZ_CP110145:5177344-5177712 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGACAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6236.72 Da        Isoelectric Point: 3.8099

>AT214587 WP_002509016.1 NZ_CP082336:873615-873785 [Staphylococcus arlettae]
MPSFNQSRNHNIEQSLKEGYSQMADLNLSLAAEAFPFECEACDCNESYISASNTND

Download         Length: 171 bp

>AT214587 NZ_CP110145:5177126-5177347 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7V7SNP8

Antitoxin

Source ID Structure
AlphaFold DB A0A7V7VEP5

References