Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 862500..863011 Replicon chromosome
Accession NZ_CP082336
Organism Staphylococcus arlettae strain AHKW2e

Toxin (Protein)


Gene name TsdT Uniprot ID A0A7V7VCW3
Locus tag K7H07_RS04080 Protein ID WP_002509005.1
Coordinates 862805..863011 (+) Length 69 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A7V7SPC1
Locus tag K7H07_RS04075 Protein ID WP_002509004.1
Coordinates 862500..862793 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K7H07_RS04055 (K7H07_04055) 858216..858851 + 636 WP_002509000.1 thiamine phosphate synthase -
K7H07_RS04060 (K7H07_04060) 858938..859804 + 867 WP_021459216.1 membrane protein insertase YidC -
K7H07_RS04065 (K7H07_04065) 860125..860751 - 627 WP_227006525.1 HD domain-containing protein -
K7H07_RS04070 (K7H07_04070) 860876..862360 - 1485 WP_002509003.1 cardiolipin synthase -
K7H07_RS04075 (K7H07_04075) 862500..862793 + 294 WP_002509004.1 copper-sensing transcriptional repressor CsoR Antitoxin
K7H07_RS04080 (K7H07_04080) 862805..863011 + 207 WP_002509005.1 hypothetical protein Toxin
K7H07_RS04085 (K7H07_04085) 863181..863321 + 141 WP_002509006.1 Lmo0850 family protein -
K7H07_RS04090 (K7H07_04090) 863368..864564 - 1197 WP_002509007.1 rod shape-determining protein RodA -
K7H07_RS04095 (K7H07_04095) 864803..865873 + 1071 WP_167868164.1 D-alanine--D-alanine ligase -
K7H07_RS04100 (K7H07_04100) 865885..867240 + 1356 WP_193325506.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(24-64)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 69 a.a.        Molecular weight: 7723.91 Da        Isoelectric Point: 5.5509

>T214586 WP_002509005.1 NZ_CP082336:862805-863011 [Staphylococcus arlettae]
MESKVIFLAGLTSYKQQAQLTQKLLNIIGVHQVHVSLEKSIVQITFDTPANLNNIEKEIYDDGYTILF

Download         Length: 207 bp

>T214586 NZ_CP110145:c4757592-4757209 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11043.67 Da        Isoelectric Point: 6.8617

>AT214586 WP_002509004.1 NZ_CP082336:862500-862793 [Staphylococcus arlettae]
MTEVDKAHHSTQTKANLKSRLNRIEGQVRAINRMIDEDVYCDDVLTQIRATRSALNSVATKLLDHHMKSCIMDKVNAGEQ
EAAMEELLVTFQKLMKD

Download         Length: 294 bp

>AT214586 NZ_CP110145:c4757834-4757592 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7V7VCW3

Antitoxin

Source ID Structure
AlphaFold DB A0A7V7SPC1

References