Detailed information of TA system TA214585

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 91647..92137
• Replicon: plasmid pEYLC1.1
• Accession: NZ_CP082334
• Organism: Exiguobacterium acetylicum strain EYLC1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A0V8GC58
• Locus tag: K7G97_RS16995
• Protein ID: WP_047395636.1
• Coordinates: 91868..92137 (+)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: K7G97_RS16990
• Protein ID: WP_223042069.1
• Coordinates: 91647..91871 (+)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K7G97_RS16970 (K7G97_16970)	86980..89109	+	2130	WP_223042065.1	heavy metal translocating P-type ATPase	-
K7G97_RS16975 (K7G97_16975)	89310..90074	-	765	WP_223042066.1	HAD-IC family P-type ATPase	-
K7G97_RS16985 (K7G97_16985)	90308..91450	+	1143	WP_223042068.1	hypothetical protein	-
K7G97_RS16990 (K7G97_16990)	91647..91871	+	225	WP_223042069.1	DUF6290 family protein	Antitoxin
K7G97_RS16995 (K7G97_16995)	91868..92137	+	270	WP_047395636.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
K7G97_RS17000 (K7G97_17000)	92509..93204	+	696	WP_035399390.1	ABC transporter ATP-binding protein	-
K7G97_RS17005 (K7G97_17005)	93197..96436	+	3240	WP_035399388.1	ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..133106	133106

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-88)

Antitoxin

• Protein of unknown function DUF6290 (1-71)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10457.13 Da
• Isoelectric Point: 10.5148

>T214585 WP_047395636.1 NZ_CP082334:91868-92137 [Exiguobacterium acetylicum]
MTAFTVEFERGAQKSLKKMDPQQARIIMSWIKKNLVGTDDPRRHGKGLVSNRSGEWRYRIGDYRLIADIQDEKVVILILE
IGHRRDIYK

Nucleotide

• Length: 270 bp

>T214585 NZ_CP110145:c4433790-4432915 [Klebsiella pneumoniae]
ATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATTTGCGCTGAAAGGTGGCACTGCCATCAATCTCTTTATCCGCGA
TTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGGTGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGG
ATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAGGCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAG
ATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAAGATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCACC
ACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTTTTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCT
ACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCATCCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAG
GAGCTTGACCGTCCCATTTTCAATGGGTTTATCGTGTATTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAATCC
TCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAATTCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGA
CAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCCTGTATCACACAACAGGATGTCGATTTTTTACTGTCATTTAAA
CGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCGTATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATAT
TCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAGATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 8581.73 Da
• Isoelectric Point: 4.5010

>AT214585 WP_223042069.1 NZ_CP082334:91647-91871 [Exiguobacterium acetylicum]
MSTISVRLDDQDTRLIKEYAKAKNITISTLVRDAVLDRIEDEIDLQLYHDSLAAHRKKSEAISFDDMMKELDLE

Nucleotide

• Length: 225 bp

>AT214585 NZ_CP110145:c4434596-4433838 [Klebsiella pneumoniae]
ATGGCAACAAAATTAAACTGGCTGCTGCAAAACAGCGCTCCCGGAGATGTGATCCTTCAGTCCTGGTTAAGCCAGCATGC
CATCTCTCCCTCTCTGGCCTTTAAATACGCGCAAAGTGGCTGGTTAAAAAAAAGAGGCAACGGCGTATATGCGCGTGCGG
GACGTGAGCCGGAGTGGAACGATGCATTAGCATGTTTGCAAAATCAGCTTGCCGCTCCGGTGTATGTTGCGGGGCTCAGT
AGCTTAGTCTGGCAGGGCCGTTCACACTATCTACAGCTAAAACAAAACCAGTGCTGGCTTAGTGTGGAAAATAAAGCGCT
GCTGCCGAAATGGTTCAGGGAATTCCCGGGTGTGGAGTGGATAGTCATATCGGGGAAAAAACTGCCGGTGCTGGATGATA
GATACCGTGTAACGCTTGATATAAAAGGGAAAAAACTCATCGGCAGTGCGCCAGAACTGGCTGCTTACGAGTTGCTGAGC
GCGGTGCCGGGGACCCTCTCATTTAACCACGCTGCAGAGCTTTTCCAGGGGCTGGTTAATCTTAATCCTCGTAAAGTAGA
GTATCTTCTTTCCGTCAGCCAGTCCGTGCAGGCCAAGCGTTTGTATCTCTTCTTCGCCAGTTTTTACGAGCATGGCTGGC
TCAAACGAATCGATAGCCAAAAAATCGATCTGGGAGCGGGCAAGCGGCAAATCGTGGAAAATGGAAAGTTCAATGCTCAA
TACCAAATCACAGTGCCTGAACGCTTTCAAAAGGAATAA

Structures

Toxin

• AlphaFold DB: A0A0V8GC58