Detailed information of TA system TA214584

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 1421778..1422268
• Replicon: chromosome
• Accession: NZ_CP082333
• Organism: Exiguobacterium acetylicum strain EYLC1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: K7G97_RS07310
• Protein ID: WP_223041798.1
• Coordinates: 1421778..1422047 (-)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: K7G97_RS07315
• Protein ID: WP_223041799.1
• Coordinates: 1422044..1422268 (-)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K7G97_RS07275 (K7G97_07275)	1417405..1417800	+	396	WP_223041793.1	hypothetical protein	-
K7G97_RS07280 (K7G97_07280)	1417845..1418225	+	381	WP_223041794.1	DUF5412 family protein	-
K7G97_RS07285 (K7G97_07285)	1418318..1418740	-	423	WP_023468065.1	hypothetical protein	-
K7G97_RS07290 (K7G97_07290)	1418828..1419535	+	708	WP_262415813.1	hypothetical protein	-
K7G97_RS07295 (K7G97_07295)	1419599..1420300	+	702	WP_223041795.1	hypothetical protein	-
K7G97_RS07300 (K7G97_07300)	1420324..1421013	+	690	WP_223041796.1	hypothetical protein	-
K7G97_RS07305 (K7G97_07305)	1421081..1421650	+	570	WP_223041797.1	suppressor of fused domain protein	-
K7G97_RS07310 (K7G97_07310)	1421778..1422047	-	270	WP_223041798.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
K7G97_RS07315 (K7G97_07315)	1422044..1422268	-	225	WP_223041799.1	DUF6290 family protein	Antitoxin
K7G97_RS07320 (K7G97_07320)	1422766..1423716	-	951	WP_223041800.1	DUF2268 domain-containing putative Zn-dependent protease	-
K7G97_RS07325 (K7G97_07325)	1423994..1424470	-	477	WP_223041801.1	tautomerase family protein	-
K7G97_RS07330 (K7G97_07330)	1424470..1424946	-	477	WP_262415814.1	heme-degrading domain-containing protein	-
K7G97_RS07335 (K7G97_07335)	1424988..1425827	-	840	WP_223041803.1	aldo/keto reductase	-
K7G97_RS07340 (K7G97_07340)	1426045..1426374	-	330	WP_035397757.1	winged helix-turn-helix transcriptional regulator	-
K7G97_RS07345 (K7G97_07345)	1426576..1427127	-	552	WP_223041804.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-88)

Antitoxin

• Protein of unknown function DUF6290 (1-71)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10500.16 Da
• Isoelectric Point: 10.3966

>T214584 WP_223041798.1 NZ_CP082333:c1422047-1421778 [Exiguobacterium acetylicum]
MTAYNVEFERGAQKSLKKMDPQQARIIMSWIKKNLVGTDDPRRHGKGLVSNRSGEWRYRIGDYRLIADIQDEKVIILILE
IGHRRDIYK

Nucleotide

• Length: 270 bp

>T214584 NZ_CP110145:c4273460-4273176 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCAGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 8657.80 Da
• Isoelectric Point: 4.4118

>AT214584 WP_223041799.1 NZ_CP082333:c1422268-1422044 [Exiguobacterium acetylicum]
MSTISVRLDDQDTRLIKEYAKAKNITISTLVRDAVLDRIEDEIDLQLYHDSMAEHRKKSEAISFDDMMKELDLE

Nucleotide

• Length: 225 bp

>AT214584 NZ_CP110145:c4273692-4273450 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCAGGGGTTAAGGTGAGTCTGGATGACCTA
TGA